T cell responses to SARS-CoV-2

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Laiqha Khadri, Mohammad Hossein Ziraksaz, Ahmad Bashir Barekzai, Baber Ghauri
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引用次数: 0

Abstract

This chapter provides a comprehensive analysis of T cell responses in COVID-19, focusing on T cell differentiation, specificity, and functional characteristics during SARS-CoV-2 infection. The differentiation of T cells in COVID-19 is explored, highlighting the key factors that influence T cell fate and effector functions. The immunology of the spike protein, a critical component of SARS-CoV-2, is discussed in detail, emphasizing its role in driving T-cell responses. The cellular immune responses against SARS-CoV-2 during acute infection are examined, including the specificity, phenotype, and functional attributes of SARS-CoV-2-specific T-cell responses. Furthermore, the chapter explores T-cell cross-recognition against other human coronaviruses (HCoVs) and the mechanisms of immune regulation mediated by spike proteins. This includes the induction of regulation through the innate immune system, the activation of self-spike protein-cross-reactive regulatory T cells, and the impact of self-tolerance on the regulation of spike proteins. The chapter investigates T cell responses to self-spike proteins and their implications in disease. The role of spike proteins as immunological targets in the context of COVID-19 is examined, shedding light on potential therapeutic interventions and clinical trials in autoimmune diseases. In conclusion, this chapter provides a comprehensive understanding of T cell responses in COVID-19, highlighting their differentiation, immune regulation, and clinical implications. This knowledge contributes to the development of targeted immunotherapies, vaccine strategies, and diagnostic approaches for COVID-19 and other related diseases.

T 细胞对 SARS-CoV-2 的反应
本章全面分析了 COVID-19 中的 T 细胞反应,重点是 SARS-CoV-2 感染期间 T 细胞的分化、特异性和功能特征。本章探讨了 COVID-19 中 T 细胞的分化,突出了影响 T 细胞命运和效应器功能的关键因素。详细讨论了尖峰蛋白(SARS-CoV-2 的关键成分)的免疫学,强调了它在驱动 T 细胞反应中的作用。本章研究了急性感染期间针对 SARS-CoV-2 的细胞免疫反应,包括 SARS-CoV-2 特异性 T 细胞反应的特异性、表型和功能属性。此外,本章还探讨了 T 细胞对其他人类冠状病毒 (HCoV) 的交叉识别以及尖峰蛋白介导的免疫调节机制。这包括通过先天性免疫系统诱导调节、激活自身尖峰蛋白交叉反应调节 T 细胞以及自身耐受性对尖峰蛋白调节的影响。本章研究了T细胞对自身尖峰蛋白的反应及其对疾病的影响。本章研究了尖峰蛋白在 COVID-19 背景下作为免疫靶点的作用,为自身免疫疾病的潜在治疗干预和临床试验提供了启示。总之,本章提供了对 COVID-19 中 T 细胞反应的全面了解,强调了它们的分化、免疫调节和临床意义。这些知识有助于开发针对 COVID-19 及其他相关疾病的靶向免疫疗法、疫苗策略和诊断方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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