Liquid Biopsy: An Emerging Diagnostic, Prognostic, and Predictive Tool in Gastric Cancer.

IF 3.2 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Gastric Cancer Pub Date : 2024-01-01 DOI:10.5230/jgc.2024.24.e5

Hye Sook Han, Keun-Wook Lee

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引用次数: 0

Abstract

Liquid biopsy, a minimally invasive procedure that causes minimal pain and complication risks to patients, has been extensively studied for cancer diagnosis and treatment. Moreover, it facilitates comprehensive quantification and serial assessment of the whole-body tumor burden. Several biosources obtained through liquid biopsy have been studied as important biomarkers for establishing early diagnosis, monitoring minimal residual disease, and predicting the prognosis and response to treatment in patients with cancer. Although the clinical application of liquid biopsy in gastric cancer is not as robust as that in other cancers, biomarker studies using liquid biopsy are being actively conducted in patients with gastric cancer. Herein, we aimed to review the role of various biosources that can be obtained from patients with gastric cancer through liquid biopsies, such as blood, saliva, gastric juice, urine, stool, peritoneal lavage fluid, and ascites, by dividing them into cellular and acellular components. In addition, we reviewed previous studies on the diagnostic, prognostic, and predictive biomarkers for gastric cancer using liquid biopsy and discussed the limitations of liquid biopsy and the challenges to overcome these limitations in patients with gastric cancer.

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液体活检：胃癌诊断、预后和预测的新兴工具

液体活检是一种微创手术，对患者造成的痛苦和并发症风险极低，已被广泛用于癌症诊断和治疗。此外，它还有助于对全身肿瘤负荷进行全面量化和连续评估。通过液体活检获得的几种生物资源已被研究为重要的生物标记物，用于癌症患者的早期诊断、监测最小残留病、预测预后和对治疗的反应。虽然液体活检在胃癌中的临床应用不如在其他癌症中那么广泛，但利用液体活检对胃癌患者进行的生物标志物研究正在积极开展。在此，我们将胃癌患者通过液体活检获得的各种生物资源，如血液、唾液、胃液、尿液、粪便、腹腔灌洗液和腹水，分为细胞成分和细胞成分，旨在回顾这些生物资源的作用。此外，我们还回顾了以往利用液体活检对胃癌的诊断、预后和预测生物标志物进行的研究，并讨论了液体活检的局限性以及在胃癌患者中克服这些局限性所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

4.30

自引率

12.00%

发文量

期刊介绍： The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.