The Role of Neutrophil in COVID-19: Positive or Negative.

IF 4.7 3区医学 Q2 IMMUNOLOGY

Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI:10.1159/000535541

Na Rong, Xiaohui Wei, Jiangning Liu

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Abstract

Background: Neutrophils are the first line of defense against pathogens. They are divided into multiple subpopulations during development and kill pathogens through various mechanisms. Neutrophils are considered one of the markers of severe COVID-19.

Summary: In-depth research has revealed that neutrophil subpopulations have multiple complex functions. Different subsets of neutrophils play an important role in the progression of COVID-19.

Key messages: In this review, we provide a detailed overview of the developmental processes of neutrophils at different stages and their recruitment and activation after SARS-CoV-2 infection, aiming to elucidate the changes in neutrophil subpopulations, characteristics, and functions after infection and provide a reference for mechanistic research on neutrophil subpopulations in the context of SARS-CoV-2 infection. In addition, we have also summarized research progress on potential targeted drugs for neutrophil immunotherapy, hoping to provide information that aids the development of therapeutic drugs for the clinical treatment of critically ill COVID-19 patients.

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中性粒细胞在 COVID-19 中的作用--积极还是消极？

背景中性粒细胞是抵御病原体的第一道防线。它们在发育过程中分为多个亚群，通过各种机制杀死病原体。中性粒细胞被认为是严重 COVID-19 的标志物之一。摘要深入研究发现，中性粒细胞亚群具有多种复杂功能。不同亚群的中性粒细胞在 COVID-19 的进展过程中发挥着重要作用。主要信息在这篇综述中，我们详细综述了中性粒细胞在不同阶段的发育过程及其在感染 SARS-CoV-2 后的招募和活化，旨在阐明中性粒细胞亚群在感染后的变化、特征和功能，为在 SARS-CoV-2 感染背景下对中性粒细胞亚群的机理研究提供参考。此外，我们还总结了中性粒细胞免疫疗法潜在靶向药物的研究进展，希望为临床治疗 COVID-19 重症患者的治疗药物开发提供信息帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Innate Immunity 医学-免疫学

CiteScore

10.50

自引率

1.90%

发文量

审稿时长

7.5 months

期刊介绍： The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.