Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia.

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Stress & Chaperones Pub Date : 2023-11-01 DOI:10.1007/s12192-023-01383-4

Christian Münch, Janine Kirstein

引用次数: 0

Abstract

Protein quality control pathways ensure a functional proteome and rely on a complex proteostasis network (PN) that is composed of molecular chaperones and proteases. Failures in the PN can lead to a broad spectrum of diseases, including neurodegenerative disorders like Alzheimer's, Parkinson's, and a range of motor neuron diseases. The EMBO workshop "Protein quality control: from molecular mechanisms to therapeutic intervention" covered all aspects of protein quality control from underlying molecular mechanisms of chaperones and proteases to stress signaling pathways and medical implications. This report summarizes the workshop and highlights selected presentations.

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蛋白质质量控制：从分子机制到治疗干预--EMBO 研讨会，2023 年 5 月 21-26 日，克罗地亚斯雷布雷诺。

蛋白质质量控制途径确保了蛋白质组的功能，并依赖于由分子伴侣和蛋白酶组成的复杂的蛋白稳态网络（PN）。蛋白稳态网络失效可导致多种疾病，包括阿尔茨海默氏症、帕金森氏症等神经退行性疾病和一系列运动神经元疾病。EMBO 研讨会 "蛋白质质量控制：从分子机制到治疗干预 "涵盖了蛋白质质量控制的各个方面，从伴侣和蛋白酶的基本分子机制到应激信号通路和医学影响。本报告对研讨会进行了总结，并重点介绍了部分演讲内容。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress & Chaperones 生物-细胞生物学

CiteScore

7.60

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.