Monitoring of optical properties of tumors during laser plasmon photothermal therapy

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-01-14 DOI:10.1002/jbio.202300322

Vadim D. Genin, Alla B. Bucharskaya, Mikhail Yu. Kirillin, Daria A. Kurakina, Nikita A. Navolokin, Georgy S. Terentyuk, Boris N. Khlebtsov, Nikolai G. Khlebtsov, Galina N. Maslyakova, Valery V. Tuchin, Elina A. Genina

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Abstract

We studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near-infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures.

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在激光等离子体光热疗法过程中监测肿瘤的光学特性。

我们研究了雄性白鼠通过皮下注射肾癌细胞获得的移植肿瘤。我们在肿瘤内注射了具有约 800 纳米等离子体共振的金纳米棒，用于光热加热。实验使用近红外二极管激光器对肿瘤进行经皮照射。研究了在质子光热疗法（PPT）作用下，所研究组织在 350-2200 纳米光谱范围内的光学特性变化。通过分析观察到的水和血红蛋白吸收带的变化，可以估算出肿瘤热损伤的深度。在上部外围部分，尤其是肿瘤囊的光谱中，观察到吸收峰明显减少。激光照射下组织光学特性的变化可用于优化实验室和临床 PPT 程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.