The Association between Cholesterol Levels and Severity of Normal Tension Glaucoma.

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2023-09-20 eCollection Date: 2023-01-01

Yu-Chieh Wu, Chien-Chih Chou, Chun-Yuan Wang

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引用次数: 0

Abstract

Purpose: To evaluate the serum lipid levels, including total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) of patients with normal tension glaucoma (NTG) and to investigate the relationship between serum HDL levels and the severity of NTG.

Methods: In this cross-sectional, case-control study, 282 NTG subjects and 202 control subjects were enrolled from the outpatient clinic of the Department of Ophthalmology at Taichung Veterans General Hospital in central Taiwan from 2015 to 2021. Fasting cholesterol, HDL, and LDL levels were evaluated using a biochemical analyzer (ARCHITECT c16000). Glaucoma severity was classified by visual field test as mild (mean deviation [MD] ≥ -6.0dB), moderate (-12dB ≤ MD < -6 dB), and severe (MD < -12dB), based on the mean deviation.

Results: HDL levels were significantly lower in the NTG group compared with the control subjects (47 ± 18mg/dl versus 53 ± 18mg/dl; p = 0.03). There were no statistically significant differences in total cholesterol or LDL levels between the NTG and control subjects (total cholesterol levels: 194 ± 39mg/dl versus 190 ± 32mg/dl; p > 0.05; LDL levels: 113 ± 30mg/dl versus 110 ± 29mg/dl; p > 0.05). The mean serum HDL levels were lowest in the severe group (41 ± 11mg/dl) followed by the moderate (45 ± 16mg/dl) and mild (50 ± 15mg/dl) groups, with significant differences among the three groups (p = 0.02). The multivariate regression analysis revealed a statistically significant negative correlation between HDL and vertical cup-to-disc ratio (VCDR; B =-0.16, p = 0.03) among all NTG patients and a positive correlation between HDL and retinal nerve fiber layer (RNFL; r = 0.34, p = 0.03) among all NTG patients.

Conclusions: A significantly lower serum HDL concentration was found in the NTG patients, which was negatively associated with disease severity. The findings warrant further study to elucidate the role of these phenomena in the pathogenesis of glaucoma.

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胆固醇水平与正常张力性青光眼严重程度之间的关系。

目的：评估正常张力青光眼（NTG）患者的血清脂质水平，包括总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL），并研究血清HDL水平与NTG严重程度之间的关系：在这项横断面病例对照研究中，2015年至2021年期间，台湾中部台中荣民总医院眼科门诊共纳入282名NTG受试者和202名对照受试者。使用生化分析仪（ARCHITECT c16000）评估空腹胆固醇、高密度脂蛋白和低密度脂蛋白水平。根据平均偏差，通过视野测试将青光眼严重程度分为轻度（平均偏差 [MD] ≥ -6.0dB）、中度（-12dB ≤ MD < -6dB）和重度（MD < -12dB）：与对照组相比，NTG 组的高密度脂蛋白水平明显较低（47 ± 18mg/dl 对 53 ± 18mg/dl；P = 0.03）。NTG组与对照组的总胆固醇或低密度脂蛋白水平差异无统计学意义（总胆固醇水平：194 ± 39mg/dl 对 190 ± 32mg/dl；p > 0.05；低密度脂蛋白水平：113 ± 30mg/dl 对 110 ± 29mg/dl；p > 0.05）。重度组的平均血清高密度脂蛋白水平最低（41 ± 11mg/dl），其次是中度组（45 ± 16mg/dl）和轻度组（50 ± 15mg/dl），三组之间差异显著（p = 0.02）。多变量回归分析显示，在所有NTG患者中，高密度脂蛋白与垂直杯盘比（VCDR；B =-0.16，P = 0.03）呈显著负相关；在所有NTG患者中，高密度脂蛋白与视网膜神经纤维层（RNFL；r = 0.34，P = 0.03）呈正相关：结论：NTG 患者的血清高密度脂蛋白浓度明显较低，且与疾病严重程度呈负相关。这些发现值得进一步研究，以阐明这些现象在青光眼发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.