Ethnic differences in cardiac structure and function assessed by MRI in healthy South Asian and White European people: A UK Biobank Study.

IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Kelly S Parke, Emer M Brady, Aseel Alfuhied, Rishabh S Motiwale, Cameron S Razieh, Anvesha Singh, Jayanth R Arnold, Matthew P M Graham-Brown, Joanna M Bilak, Sarah L Ayton, Abhishek Dattani, Jian L Yeo, Gerry P McCann, Gaurav S Gulsin
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引用次数: 0

Abstract

Background: Echocardiographic studies indicate South Asian people have smaller ventricular volumes, lower mass and more concentric remodelling than White European people, but there are no data using cardiac MRI (CMR). We aimed to compare CMR quantified cardiac structure and function in White European and South Asian people.

Methods: Healthy White European and South Asian participants in the UK Biobank Imaging CMR sub-study were identified by excluding those with a history of cardiovascular disease, hypertension, obesity or diabetes. Ethnic groups were matched by age and sex. Cardiac volumes, mass and feature tracking strain were compared.

Results: 121 matched pairs (77 male/44 female, mean age 58 ± 8 years) of South Asian and White European participants were included. South Asian males and females had smaller absolute but not indexed left ventricular (LV) volumes, and smaller absolute and indexed right ventricular volumes, with lower absolute and indexed LV mass and lower LV mass:volume than White European participants. Although there were no differences in ventricular or atrial ejection fractions, LV global longitudinal strain was higher in South Asian females than White European females but not males, and global circumferential strain was higher in both male and South Asian females than White European females. Peak early diastolic strain rates were higher in South Asian versus White European males, but not different between South Asian and White European females.

Conclusions: Contrary to echocardiographic studies, South Asian participants in the UK Biobank study had less concentric remodelling and higher global circumferential strain than White European subjects. These findings emphasise the importance of sex- and ethnic- specific normal ranges for cardiac volumes and function.

通过核磁共振成像评估健康的南亚人和欧洲白人在心脏结构和功能方面的种族差异:英国生物库研究。
背景:超声心动图研究表明,与欧洲白人相比,南亚人的心室容积较小,质量较低,同心重塑较多,但没有使用心脏磁共振成像(CMR)的数据。我们的目的是比较欧洲白人和南亚人通过 CMR 量化的心脏结构和功能。方法:英国生物库成像 CMR 子研究的健康欧洲白人和南亚人参与者均排除了有心血管疾病、高血压、肥胖或糖尿病病史者。各民族按年龄和性别进行匹配。比较了心脏体积、质量和特征跟踪应变:结果:共纳入了 121 对匹配的南亚和欧洲白人参与者(77 男/44 女,平均年龄 58±8 岁)。与欧洲白人参与者相比,南亚男性和女性的左心室绝对容积较小,但指数化左心室容积较小,右心室绝对容积和指数化右心室容积较小,左心室绝对质量和指数化质量较低,左心室质量:容积较低。虽然心室或心房射血分数没有差异,但南亚女性的左心室整体纵向应变高于欧洲白人女性,而男性则没有差异;男性和南亚女性的左心室整体环向应变均高于欧洲白人女性。南亚男性与欧洲白人男性相比,舒张早期的峰值应变率更高,但南亚女性与欧洲白人女性之间没有差异:结论:与超声心动图研究相反,英国生物样本库研究中的南亚参与者与欧洲白人受试者相比,同心重塑程度较低,总体圆周应变较高。这些发现强调了针对不同性别和种族的心脏容积和功能正常范围的重要性。
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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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