Flare levels after intravitreal injection of brolucizumab for diabetic macular edema

Graefe's Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-01-13 DOI:10.1007/s00417-024-06374-4

Yushi Ichihashi, Yoshihiro Takamura, Takao Hirano, Masahiko Shimura, Keisuke Yoneda, Keiichiro Konno, Yutaka Yamada, Masakazu Morioka, Makoto Gozawa, Takehiro Matsumura, Masaru Inatani

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Abstract

Purpose

This study aimed to evaluate anterior flare intensity (AFI) after intravitreal injection of brolucizumab (IVBr) in patients with diabetic macular edema (DME), and to identify the factors associated with the change of AFI after IVBr.

Methods

This prospective multicenter study was conducted at five sites in Japan for patients with DME who underwent a single IVBr. AFI and central retinal thickness (CRT) were measured using a laser flare meter and spectral-domain optical coherence tomography, respectively, at weeks 0 and 6.

Results

Sixty-five patients (phakia, 37 eyes; pseudophakia, 28 eyes) were enrolled. Six weeks after IVBr, CRT and best-corrected visual acuity significantly improved (p < 0.0001). AFI (p = 0.0003) and age (p = 0.0054) were significantly higher in patients with pseudophakic eyes than those with phakic eyes. The AFI of the phakic eyes decreased after IVBr (p = 0.043). As the AFI before injection is higher (p = 0.0363) and the age is lower (p = 0.0016), the AFI decreases after IVBr. There was a significant positive correlation between the rates of change in CRT and AFI (p = 0.024).

Conclusion

After IVBr, AFI decreases in phakic eyes but not in pseudophakic eyes. The age, AFI and CRT before injection and changes of CRT are involved in the change in AFI after IVBr.

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糖尿病黄斑水肿玻璃体内注射博路单抗后的耀斑水平

目的本研究旨在评估糖尿病性黄斑水肿（DME）患者玻璃体内注射brolucizumab（IVBr）后的前方耀斑强度（AFI），并确定与IVBr后AFI变化相关的因素。方法这项前瞻性多中心研究在日本的五个地点进行，对象是接受单次IVBr治疗的DME患者。在第 0 周和第 6 周，分别使用激光耀斑仪和光谱域光学相干断层扫描测量 AFI 和视网膜中央厚度 (CRT)。IVBr 六周后，CRT 和最佳矫正视力明显改善（p < 0.0001）。假性眼患者的 AFI（p = 0.0003）和年龄（p = 0.0054）明显高于法眼患者。注射 IVBr 后，法眼患者的 AFI 有所下降（p = 0.043）。由于注射前 AFI 较高（p = 0.0363），年龄较低（p = 0.0016），IVBr 后 AFI 有所下降。 CRT 和 AFI 的变化率之间存在显著的正相关（p = 0.024）。年龄、注射前的 AFI 和 CRT 以及 CRT 的变化与 IVBr 后 AFI 的变化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Graefe's Archive for Clinical and Experimental Ophthalmology

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