Vasculitic Neuropathies

IF 2 4区医学 Q1 Medicine

Current Treatment Options in Neurology Pub Date : 2024-01-11 DOI:10.1007/s11940-024-00782-x

Avi Landman, Mark Levine, Andrés M. De León

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引用次数: 0

Abstract

Purpose of review

To describe the clinical presentation, diagnosis, and treatment options of vasculitic neuropathies. Overall, vasculitic neuropathies can be divided into systemic and nonsystemic. Systemic vasculitic neuropathies form part of rheumatological diseases, where in some cases, the vasculitic is the predominant feature, and these are called primary vasculitis, while in others, the vasculitis is secondary to a connective tissue disease. Nonsystemic vasculitic neuropathies involve only the peripheral nervous system, and thus, diagnosis is more challenging as it requires a high degree of suspicion and confirmation with nerve biopsy results.

Recent findings

Over the past few years, rituximab has been increasingly used for induction and maintenance treatment of vasculitis due to a more favorable side effect profile and similar efficacy when compared to cyclophosphamide.

Summary

Herein, we describe the different types of vasculitic neuropathies. Regarding their treatment, have focused on the indications, dosing, and side effects for the most common options for primary systemic vasculitic neuropathies, as these tend to be similar for the classical nonsystemic vasculitic neuropathy phenotype.

Abstract Image

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血管炎性神经病

综述目的描述血管炎性神经病的临床表现、诊断和治疗方案。总的来说，血管神经病可分为系统性和非系统性两种。全身性血管炎性神经病是风湿病的一部分，在某些病例中，血管炎是主要特征，这些病例被称为原发性血管炎，而在另一些病例中，血管炎是继发于结缔组织病。非系统性血管炎性神经病仅累及外周神经系统，因此诊断更具挑战性，需要高度怀疑并通过神经活检结果进行确认。最近的研究结果在过去几年中，利妥昔单抗因其与环磷酰胺相比更有利的副作用和相似的疗效，越来越多地被用于血管炎的诱导和维持治疗。在治疗方面，我们重点介绍了原发性系统性血管性神经病最常见方案的适应症、用药剂量和副作用，因为这些方案往往与经典的非系统性血管性神经病表型相似。

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来源期刊

Current Treatment Options in Neurology CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published treatment option advances in the field of neurology. By presenting clear, insightful, balanced contributions by international experts, the journal intends to facilitate worldwide approaches to the treatment of neurologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as epilepsy, headache, neurologic ophthalmology and otology, neuromuscular disorders, psychiatric manifestations of neurologic disease, and sleep disorders. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known neurologists, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.