Arwa A. Abugable , Sarah Antar , Sherif F. El-Khamisy
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引用次数: 0
Abstract
Cells are constantly exposed to various sources of DNA damage that pose a threat to their genomic integrity. One of the most common types of DNA breaks are single-strand breaks (SSBs). Mutations in the repair proteins that are important for repairing SSBs have been reported in several neurological disorders. While several tools have been utilised to investigate SSBs in cells, it was only through recent advances in genomics that we are now beginning to understand the architecture of the non-random distribution of SSBs and their impact on key cellular processes such as transcription and epigenetic remodelling. Here, we discuss our current understanding of the genome-wide distribution of SSBs, their link to neurological disorders and summarise recent technologies to investigate SSBs at the genomic level.
细胞经常会受到各种 DNA 损伤，对其基因组的完整性构成威胁。单链断裂（SSB）是最常见的 DNA 断裂类型之一。据报道，在几种神经系统疾病中，对修复单链断裂非常重要的修复蛋白发生了突变。虽然已有多种工具用于研究细胞中的单链断裂，但直到最近基因组学的发展，我们才开始了解单链断裂非随机分布的结构及其对转录和表观遗传重塑等关键细胞过程的影响。在这里，我们将讨论我们目前对 SSB 的全基因组分布、它们与神经系统疾病的联系的理解，并总结最近在基因组水平上研究 SSB 的技术。
期刊介绍：
DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease.
DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.
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