Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-01-11 DOI:10.1038/s41429-023-00696-x

Haruki Azami, Yoshihiro Watanabe, Kazunari Sakai, Hiroki Nakahara, Hiroki Kojima, Toshiyuki Tokiwa, Kenichi Nonaka, Yoshihiko Noguchi, Yuriko Nagano, Tomoyasu Hirose, Toshiaki Sunazuka, Hidehito Matsui, Naoaki Arima, Kazutoyo Abe, Hideaki Hanaki, Masato Iwatsuki

引用次数: 0

Abstract

A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity against clinically isolated Candida auris strains, with MIC values ranging from 0.0625 to 4 µg ml–1.

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由深海源真菌菌株 Scedosporium apiospermum FKJ-0499 产生的酪酸菌素及其新类似物对白色念珠菌临床分离株的抗真菌谱。

从深海沉积物样本中分离出的静态真菌培养物 Scedosporium apiospermum FKJ-0499 和已知化合物 tyroscherin（2）中发现了一种新的抗真菌化合物，命名为 N-去甲基 tyroscherin（1）。通过质谱和核磁共振分析，1 的结构被阐明为 2 的新类似物。通过化学衍生法确定了 1 的绝对构型。这两种化合物对临床分离的白色念珠菌菌株都表现出了很强的体外抗真菌活性，其 MIC 值从 0.0625 到 4 µg ml-1 不等。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.