Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall.

IF 2.5 4区生物学 Q3 CELL BIOLOGY

Histology and histopathology Pub Date : 2024-08-01 Epub Date: 2023-12-22 DOI:10.14670/HH-18-696

Linwei Zuo, Huiyan You, Zhe Cai, Shousheng Liao, Xiangtong Lu, Lixiang Li, Wenyong Huang

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引用次数: 0

Abstract

Background: Melan-A/MART-1 is a melanocytic differentiation marker recognized as an antigen on melanoma cells. It is a useful diagnostic marker for pathologists in the diagnosis of melanocytic tumors. However, we recently found that Melan-A can be expressed in some non-melanocytic carcinomas that are rarely reported in the literature.

Methods: We analyzed the expression of Melan-A in 87 non-melanocytic carcinoma tissue samples by immunohistochemistry. Marker positivity was defined as ≥10% positive tumor cells.

Results: In 87 non-melanocytic carcinoma tissue samples, Melan-A was positive in six (6.89%) cases, of which four (66.7%) were male and two (33.3%) were female, with a mean age of 60 years (range 21-82 years). Five (83.3%) of the Melan-A-positive cases had distant metastases. Compared with Melan-A negative cases, Melan-A positive non-melanocytic carcinomas were significantly associated with poor prognosis (P=0.0023).

Conclusions: Melan-A expression is relatively rare in non-melanocytic carcinoma cases. This report highlights a potential diagnostic pitfall in the diagnosis of melanoma, urges pathologists to exercise caution in cases of Melan-A positivity, and illustrates the need for an immunohistochemical marker panel to avoid misdiagnosis.

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非黑色素细胞癌中的 Melan-A 表达：潜在的诊断陷阱。

背景：Melan-A/MART-1 是一种黑色素细胞分化标记，是黑色素瘤细胞上的抗原。它是病理学家诊断黑色素细胞肿瘤的有用标志物。然而，我们最近发现，Melan-A 可在一些非黑色素细胞癌中表达，而这些非黑色素细胞癌在文献中鲜有报道：方法：我们采用免疫组化方法分析了 87 例非黑色素细胞癌组织样本中 Melan-A 的表达情况。标记物阳性定义为阳性肿瘤细胞≥10%：在 87 例非黑色素细胞癌组织样本中，有 6 例（6.89%）Melan-A 阳性，其中 4 例（66.7%）为男性，2 例（33.3%）为女性，平均年龄为 60 岁（21-82 岁）。5例（83.3%）Melan-A阳性病例有远处转移。与Melan-A阴性病例相比，Melan-A阳性非黑色素细胞癌与预后不良显著相关（P=0.0023）：结论：Melan-A表达在非黑色素细胞癌中相对罕见。本报告强调了黑色素瘤诊断中的一个潜在诊断陷阱，敦促病理学家在Melan-A阳性病例中谨慎从事，并说明需要免疫组化标记物面板来避免误诊。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histology and histopathology 生物-病理学

CiteScore

3.90

自引率

0.00%

发文量

232

审稿时长

2 months

期刊介绍： HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.