Application of quantitative orbital analysis to assess the activity of Graves' ophthalmopathy.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

American journal of nuclear medicine and molecular imaging Pub Date : 2023-12-25 eCollection Date: 2023-01-01

Shuang Li, Yue-Jun Liu

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引用次数: 0

Abstract

This study aimed to evaluate the diagnostic value of uptake ratios in the extraocular muscles (EOMs), lacrimal glands, and optic nerves to detect the inflammation activity of Graves' ophthalmopathy (GO) using quantitative analysis of 99m technetium (^99mTc)-labeled diethylene triamine pentaacetic acid (DTPA) orbital single-photon emission computed tomography/computed tomography (SPECT/CT) images. The patients were categorized into an active stage (clinical activity score ≥ 3/7, n=23) or an inactive stage (clinical activity score < 3/7, n=38), based on their clinical activity score. The uptake ratio was manually determined by placing a region of interest within the area of highest uptake, as agreed upon by consensus, in the EOMs, lacrimal gland, and optic nerve on SPECT images corrected for CT attenuation. Patients with active GO exhibited significantly higher uptake ratios in the EOMs, lacrimal glands, and optic nerves compared to patients with inactive GO (all P < 0.01). These parameters have been proven effective in differentiating between active and inactive disease.

本刊更多论文

应用眼眶定量分析评估巴塞杜氏眼病的活动性。

本研究旨在通过定量分析99m锝（99mTc）标记的二乙三胺五醋酸（DTPA）眼眶单光子发射计算机断层扫描（SPECT/CT）图像，评估眼外肌（EOMs）、泪腺和视神经的摄取比率对检测巴塞杜氏眼病（Graves' ophthalmopathy，GO）炎症活动的诊断价值。根据临床活动评分，将患者分为活动期（临床活动评分≥ 3/7，23 人）和非活动期（临床活动评分< 3/7，38 人）。摄取比是人工确定的，方法是在SPECT图像上经CT衰减校正的EOM、泪腺和视神经摄取最高的区域内放置一个感兴趣区。与非活动性GO患者相比，活动性GO患者的眼表、泪腺和视神经的摄取率明显更高（P均<0.01）。这些参数已被证明能有效区分活动性和非活动性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.