Investigation of the association between the Toll-like receptor 1 rs4833095 variation and gastric adenocarcinoma recurrence

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Annals of Human Genetics Pub Date : 2024-01-09 DOI:10.1111/ahg.12548

Yuan Dang, Jingyun Huang, Chen Lin, Shaohua Xu

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引用次数: 0

Abstract

Background

Toll-like receptors (TLRs) are a family of transmembrane receptors that play key roles in identifying invading pathogens and activating innate immunity. TLR1 has been reported to be associated with the risk of gastric cancer (GC) but that was based on only a simple statistical analysis.

Methods

We genotyped the TLR1 in 526 GC patients to investigate the association between the variation and gastric cancer survival by the multiplex polymerase chain reaction and sequencing method. The rs4833095 variation (chr4:38798089 [GRCh38. p14], T > C) in the TLR1 gene was genotyped in 526 patients who underwent GC resection. The associations between genotype, survival, and recurrence were investigated. The potential role of TLR1 in stomach cancer was investigated using clinical data from formalin-fixed, paraffin-embedded tissue samples.

Results

Patients with the T/C and C/C genotypes of rs4833095 had a lower risk of recurrence than those with the T/T genotype. Recurrence-free periods were substantially longer in patients with the T/C or C/C genotypes (22.6 and 22.3 months, respectively) than in those with the T/T genotype (20.7 months). Patients with the T/C or C/C genotype, low expression levels of VEGF1, high expression levels of ERBB2 and ERCC1, the absence of cancer nodules, a tumor size of less than 5 cm, and poor differentiation had a considerably reduced risk of recurrence.

Conclusions

TLR1 rs4833095 was correlated with the postresection prognosis of patients with gastric cancer, suggesting that TLR1 may have a role in the onset or progression of gastric cancer.

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Toll 样受体 1 rs4833095 变异与胃腺癌复发之间关系的研究

背景：Toll样受体（TLRs）是一种跨膜受体，在识别入侵病原体和激活先天性免疫方面发挥着关键作用。有报道称 TLR1 与胃癌（GC）风险有关，但这只是基于简单的统计分析：方法：我们对 526 例 GC 患者的 TLR1 进行了基因分型，通过多重聚合酶链反应和测序方法研究了变异与胃癌生存之间的关系。我们对 526 例接受胃癌切除术的患者进行了 TLR1 基因 rs4833095 变异（chr4:38798089 [GRCh38. p14]，T > C）的基因分型。研究调查了基因型、生存率和复发率之间的关系。利用福尔马林固定、石蜡包埋组织样本的临床数据，研究了 TLR1 在胃癌中的潜在作用：结果：rs4833095 的 T/C 和 C/C 基因型患者的复发风险低于 T/T 基因型患者。T/C或C/C基因型患者的无复发期（分别为22.6个月和22.3个月）大大长于T/T基因型患者（20.7个月）。T/C或C/C基因型、血管内皮生长因子1表达水平低、ERBB2和ERCC1表达水平高、无癌结节、肿瘤大小小于5厘米以及分化差的患者的复发风险大大降低：结论：TLR1 rs4833095与胃癌患者切除术后的预后相关，表明TLR1可能在胃癌的发生或发展中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Genetics 生物-遗传学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.