Post-Traumatic Cerebral Infarction: A Narrative Review of Pathophysiology, Diagnosis, and Treatment

IF 3.2 Q2 CLINICAL NEUROLOGY
Roy A Poblete, Charlotte Zhong, Anish Patel, Grace Kuo, Philip Sun, Jiayu Xiao, Zhaoyang Fan, N. Sanossian, A. Towfighi, Patrick D. Lyden
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引用次数: 0

Abstract

Traumatic brain injury (TBI) is a common diagnosis requiring acute hospitalization. Long-term, TBI is a significant source of health and socioeconomic impact in the United States and globally. The goal of clinicians who manage TBI is to prevent secondary brain injury. In this population, post-traumatic cerebral infarction (PTCI) acutely after TBI is an important but under-recognized complication that is associated with negative functional outcomes. In this comprehensive review, we describe the incidence and pathophysiology of PTCI. We then discuss the diagnostic and treatment approaches for the most common etiologies of isolated PTCI, including brain herniation syndromes, cervical artery dissection, venous thrombosis, and post-traumatic vasospasm. In addition to these mechanisms, hypercoagulability and microcirculatory failure can also exacerbate ischemia. We aim to highlight the importance of this condition and future clinical research needs with the goal of improving patient outcomes after TBI.
创伤后脑梗塞:病理生理学、诊断和治疗综述
创伤性脑损伤(TBI)是一种需要急性住院治疗的常见诊断。长期来看,创伤性脑损伤对美国乃至全球的健康和社会经济都造成了重大影响。处理创伤性脑损伤的临床医生的目标是防止继发性脑损伤。在这些人群中,创伤性脑损伤后急性脑梗塞(PTCI)是一种重要的并发症,但却未得到充分认识,它与不良的功能预后有关。在这篇综述中,我们将介绍 PTCI 的发病率和病理生理学。然后,我们讨论了孤立性 PTCI 最常见病因的诊断和治疗方法,包括脑疝综合征、颈动脉夹层、静脉血栓和创伤后血管痉挛。除这些机制外,高凝状态和微循环衰竭也会加重缺血。我们旨在强调这种情况的重要性和未来的临床研究需求,以改善创伤性脑损伤后患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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