Evaluation of the Influence of Geodimensional and Histological Parameters on the Need for Margin Widening in Breast Lesions Marked With Magnetic Seeds.

IF 1.3 Q4 ONCOLOGY
European journal of breast health Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI:10.4274/ejbh.galenos.2023.2023-11-5
João T Oliveira, Ana Munhoz, Jm Preza Fernandes, Cláudia Paiva, Tânia Teixeira, Susana Marta, José Polónia
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引用次数: 0

Abstract

Objective: Breast cancer is an important topic worldwide, posing morbidity and mortality to women. Considerable efforts have been put in the early recognition of malignancy through different screening methods, such as mammography and ultrasound. The precise localization of infraclinical malignant lesions is key in surgical management and magnetic seeds gather particular interest for this purpose. As with other systems, a need for reintervention may be needed to obtain adequate surgical margins. This work evaluated the relation between the need for surgical reintervention in order to obtain negative margins and geodimensional and histological parameters. The main objective was the identification of parameters significantly associated with reintervention for margin widening.

Materials and methods: A retrospective analysis of 198 patients from a single centre was performed. The association between pre-defined geodimensional and histological parameters and the need for margin widening in infraclinical lesions marked with magnetic seed was evaluated.

Results: Results showed that reintervention to widen margins was significantly higher in patients with ductal carcinoma in situ (DCIS) in the pre-operative biopsy when compared with invasive carcinoma (p = 0.03) in the bivariate analysis. No statistically significant differences were observed between the need for reintervention and lesion size (p = 0.197), breast quadrant location (p = 0.626) and distance of skin to lesion (p = 0.356).

Conclusion: This work suggests that a more invasive margin clearance in lesions with a pre-operative DCIS diagnosis might obviate the need for reintervention to obtain negative margins. On the other hand, it is not necessary to be surgically more invasive in larger lesions, deeply located or that are present in a certain quadrant, since there are no significant differences regarding the need for reintervention.

评估地理尺寸和组织学参数对磁性粒子标记乳腺病变边缘扩大需求的影响
目的:乳腺癌是全世界的一个重要话题,它给妇女带来了发病率和死亡率。通过乳房 X 射线照相术和超声波等不同的筛查方法,人们在早期识别恶性肿瘤方面做出了巨大努力。临床下恶性病变的精确定位是手术治疗的关键,磁性种子在这方面尤其受到关注。与其他系统一样,为了获得足够的手术边缘,可能需要再次介入。这项研究评估了为获得阴性边缘而进行手术再介入的必要性与几何尺寸和组织学参数之间的关系。主要目的是确定与边缘增宽而再次介入手术显著相关的参数:对一个中心的 198 例患者进行了回顾性分析。评估了预先确定的几何尺寸和组织学参数与临床下病灶磁性种子标记边缘扩大需求之间的关联:结果:结果显示,在双变量分析中,术前活检结果为乳腺导管原位癌(DCIS)的患者与浸润癌患者相比,扩大边缘的再次干预率明显更高(P = 0.03)。再次干预的必要性与病灶大小(p = 0.197)、乳腺象限位置(p = 0.626)和皮肤到病灶的距离(p = 0.356)之间没有统计学差异:这项研究表明,对术前诊断为 DCIS 的病变进行更具创伤性的边缘清理,可避免为获得阴性边缘而再次进行手术。另一方面,对于病灶较大、位置较深或存在于某一象限的病灶,由于再次介入的必要性没有显著差异,因此没有必要采取更具创伤性的手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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