Kinga Humińska-Lisowska, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Strońska, Paweł Cięszczyk, Michał Spieszny, Jolanta Masiak, Milena Lachowicz, Olga Surała, Anna Grzywacz
{"title":"Association between polymorphism rs6295 of <i>HTR1A</i> serotonin receptor gene and personality traits among athletes of combat sport.","authors":"Kinga Humińska-Lisowska, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Strońska, Paweł Cięszczyk, Michał Spieszny, Jolanta Masiak, Milena Lachowicz, Olga Surała, Anna Grzywacz","doi":"10.5114/biolsport.2024.129478","DOIUrl":null,"url":null,"abstract":"<p><p><i>HTR1A</i> (5-hydroxytryptamine receptor 1A) and its polymorphic variants are highly important for athletes in different aspects, allowing us to hypothesize their biological influences. Hence, to investigate at least part of the relationship mentioned in the case literature, it was decided to study the association of the selected <i>HTR1A</i> polymorphism with personality traits measured by the Temperament and Character Inventory (TCI). The participants consisted of 250 mixed martial arts (combat sport) athletes and 209 healthy male participants (control group). The personality traits were measured for the Revised Temperament and Character Inventory (TCI-R). Genetic material was isolated from whole blood collected from patients, and then all samples were genotyped using the real-time PCR method. Statistical analysis was performed using a 2 × 3 factorial ANOVA. The research revealed a statistically significant effect of a complex factor of rs6295 of the <i>HTR1A</i> serotonin receptor gene with combat sport/control and with Novelty Seeking (F<sub>2,453</sub> = 6.126; <i>p</i> = 0.0024; η<sup>2</sup> = 0.026) and Harm Avoidance (F<sub>2,453</sub> = 3.709; <i>p</i> = 0.0252; η<sup>2</sup> = 0.016). The presence of the <i>HTR1A</i> GG genotype (rs6295) was found to be associated with higher scores in self-management and lower scores in harm avoidance, indicating genetic predispositions in the strength group towards better results in combat sports.</p>","PeriodicalId":55365,"journal":{"name":"Biology of Sport","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10765443/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology of Sport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/biolsport.2024.129478","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
HTR1A (5-hydroxytryptamine receptor 1A) and its polymorphic variants are highly important for athletes in different aspects, allowing us to hypothesize their biological influences. Hence, to investigate at least part of the relationship mentioned in the case literature, it was decided to study the association of the selected HTR1A polymorphism with personality traits measured by the Temperament and Character Inventory (TCI). The participants consisted of 250 mixed martial arts (combat sport) athletes and 209 healthy male participants (control group). The personality traits were measured for the Revised Temperament and Character Inventory (TCI-R). Genetic material was isolated from whole blood collected from patients, and then all samples were genotyped using the real-time PCR method. Statistical analysis was performed using a 2 × 3 factorial ANOVA. The research revealed a statistically significant effect of a complex factor of rs6295 of the HTR1A serotonin receptor gene with combat sport/control and with Novelty Seeking (F2,453 = 6.126; p = 0.0024; η2 = 0.026) and Harm Avoidance (F2,453 = 3.709; p = 0.0252; η2 = 0.016). The presence of the HTR1A GG genotype (rs6295) was found to be associated with higher scores in self-management and lower scores in harm avoidance, indicating genetic predispositions in the strength group towards better results in combat sports.
期刊介绍:
Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984.
Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.