Association between polymorphism rs6295 of HTR1A serotonin receptor gene and personality traits among athletes of combat sport.

IF 4.2 2区 医学 Q1 SPORT SCIENCES
Biology of Sport Pub Date : 2024-01-01 Epub Date: 2023-09-20 DOI:10.5114/biolsport.2024.129478
Kinga Humińska-Lisowska, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Strońska, Paweł Cięszczyk, Michał Spieszny, Jolanta Masiak, Milena Lachowicz, Olga Surała, Anna Grzywacz
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引用次数: 0

Abstract

HTR1A (5-hydroxytryptamine receptor 1A) and its polymorphic variants are highly important for athletes in different aspects, allowing us to hypothesize their biological influences. Hence, to investigate at least part of the relationship mentioned in the case literature, it was decided to study the association of the selected HTR1A polymorphism with personality traits measured by the Temperament and Character Inventory (TCI). The participants consisted of 250 mixed martial arts (combat sport) athletes and 209 healthy male participants (control group). The personality traits were measured for the Revised Temperament and Character Inventory (TCI-R). Genetic material was isolated from whole blood collected from patients, and then all samples were genotyped using the real-time PCR method. Statistical analysis was performed using a 2 × 3 factorial ANOVA. The research revealed a statistically significant effect of a complex factor of rs6295 of the HTR1A serotonin receptor gene with combat sport/control and with Novelty Seeking (F2,453 = 6.126; p = 0.0024; η2 = 0.026) and Harm Avoidance (F2,453 = 3.709; p = 0.0252; η2 = 0.016). The presence of the HTR1A GG genotype (rs6295) was found to be associated with higher scores in self-management and lower scores in harm avoidance, indicating genetic predispositions in the strength group towards better results in combat sports.

HTR1A血清素受体基因多态性rs6295与搏击运动员人格特质的关系
HTR1A(5-羟色胺受体 1A)及其多态变体在不同方面对运动员都非常重要,因此我们可以推测其生物学影响。因此,为了研究案例文献中提到的至少部分关系,我们决定研究选定的 HTR1A 多态性与气质和性格量表(TCI)测量的性格特征之间的关系。参与者包括 250 名综合格斗(搏击运动)运动员和 209 名健康男性参与者(对照组)。人格特质通过修订版气质与性格量表(TCI-R)进行测量。从患者的全血中分离出遗传物质,然后使用实时 PCR 方法对所有样本进行基因分型。统计分析采用 2 × 3 方差分析。研究发现,HTR1A 血清素受体基因 rs6295 的复合因子对格斗运动/控制以及寻求新奇(F2,453 = 6.126; p = 0.0024; η2 = 0.026)和避免伤害(F2,453 = 3.709; p = 0.0252; η2 = 0.016)的影响具有统计学意义。研究发现,HTR1A GG 基因型(rs6295)的存在与较高的自我管理得分和较低的伤害规避得分有关,这表明力量组的遗传倾向有利于在格斗运动中取得更好的成绩。
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来源期刊
Biology of Sport
Biology of Sport 生物-运动科学
CiteScore
8.20
自引率
12.50%
发文量
113
审稿时长
>12 weeks
期刊介绍: Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984. Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.
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