Dietary insulin indices and low-carbohydrate diet and the odds of colorectal cancer: a case-control study.

IF 2.1 4区医学 Q3 ONCOLOGY

European Journal of Cancer Prevention Pub Date : 2024-07-01 Epub Date: 2023-12-18 DOI:10.1097/CEJ.0000000000000867

Alireza Bahrami, Karim Parastouei, Maryam Taghdir, Mojtaba Ghadyani

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引用次数: 0

Abstract

Background: Regarding the role of insulin and insulin-inducing dietary factors in some cancers' etiology, we hypothesized that the risk of colorectal cancer may be lessened by following a lower carbohydrate and insulinogenic diet. Therefore, we performed this study to explore the association between a low-carbohydrate diet and insulin indices and the odds of colorectal cancer.

Method: This hospital-based case-control study was conducted on 150 newly diagnosed colorectal cancer patients and 300 healthy age- and sex-matched hospitalized controls. A valid and reliable food frequency questionnaire was used to calculate the insulin indices and low-carbohydrate diet score. Multivariate logistic regression was used to estimate the association between insulin indices and low-carbohydrate diet and the odds of colorectal cancer.

Result: After adjusting for potential confounders, individuals in the highest tertile of insulin indices had a higher risk of colorectal cancer (OR insulin index = 3.46; 95% CI, 2.00-5.96; OR insulin load = 2; 95% CI, 1.17-3.41). No association was found between a low-carbohydrate diet and colorectal cancer (OR = 1.55; 95% CI, 0.85-2.84).

Conclusion: Current results demonstrated that a high insulinemic diet was associated with a higher risk of colorectal cancer.

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膳食胰岛素指数和低碳水化合物饮食与结直肠癌发病几率：一项病例对照研究。

背景：鉴于胰岛素和胰岛素诱导饮食因素在某些癌症的病因学中的作用，我们假设，采用低碳水化合物和胰岛素诱导饮食可能会降低结直肠癌的风险。因此，我们进行了这项研究，探讨低碳水化合物饮食和胰岛素指数与结直肠癌发病几率之间的关系：这项以医院为基础的病例对照研究针对 150 名新确诊的结直肠癌患者和 300 名年龄和性别匹配的健康住院对照者。采用有效可靠的食物频率调查问卷计算胰岛素指数和低碳水化合物饮食评分。采用多元逻辑回归法估算胰岛素指数和低碳水化合物饮食与结直肠癌发病几率之间的关系：结果：在对潜在的混杂因素进行调整后，胰岛素指数处于最高三分位的人患结直肠癌的风险更高（OR胰岛素指数=3.46；95% CI，2.00-5.96；OR胰岛素负荷=2；95% CI，1.17-3.41）。低碳水化合物饮食与结直肠癌之间没有关联（OR = 1.55；95% CI，0.85-2.84）：目前的研究结果表明，高胰岛素饮食与罹患结直肠癌的风险较高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Cancer Prevention 医学-肿瘤学

CiteScore

4.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： European Journal of Cancer Prevention aims to promote an increased awareness of all aspects of cancer prevention and to stimulate new ideas and innovations. The Journal has a wide-ranging scope, covering such aspects as descriptive and metabolic epidemiology, histopathology, genetics, biochemistry, molecular biology, microbiology, clinical medicine, intervention trials and public education, basic laboratory studies and special group studies. Although affiliated to a European organization, the journal addresses issues of international importance.