Comparing the effects of lycopene and corticosteroids on oral lichen planus: a systematic review and meta-analysis

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of HerbMed Pharmacology Pub Date : 2023-06-01 DOI:10.34172/jhp.2023.36

P. Motahari, Rana Daliraan, Solmaz Poorzare

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引用次数: 0

Abstract

Oral lichen planus (OLP) as an inflammatory disease is autoimmune in nature and there is no definitive treatment for it. Currently, topical and systemic corticosteroids have been adopted as the gold standard in the treatment of OLP, which have significant side effects. Nowadays, the tendency towards natural medicines with antioxidant properties as an alternative treatment has increased due to their low side effects. The main purpose of this systematic review and meta-analysis was to focus on comparing the effects of lycopene as an herbal intervention and corticosteroids on OLP in clinical trials. The search using keywords was done through provided databases from PubMed, Web of Science, Google Scholar, and Scopus until March 2023. After removing duplicate articles and screening them according to eligibility criteria, 5 articles remained and were considered for systematic review and meta-analysis. According to the meta-analysis, significant difference was not observed between the lycopene and corticosteroid groups in terms of reducing pain and improving clinical symptoms after treatment. Lycopene was tolerated well and no specific adverse effects were shown. The systematic review results showed the significant effect of lycopene in the treatment of OLP. The results of this meta-analysis can be useful because no significant side effects have been specified for lycopene. Hence, it might be used instead of steroids.

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比较番茄红素和皮质类固醇对口腔扁平苔藓的影响：系统综述和荟萃分析

口腔扁平苔藓（OLP）是一种自身免疫性炎症疾病，目前尚无确切的治疗方法。目前，局部和全身使用皮质类固醇激素已成为治疗口腔扁平苔藓的金标准，但其副作用很大。如今，具有抗氧化特性的天然药物因其副作用小而越来越多地被用作替代治疗方法。本系统综述和荟萃分析的主要目的是在临床试验中重点比较番茄红素作为一种草药干预措施与皮质类固醇对OLP的影响。本研究使用关键词在PubMed、Web of Science、Google Scholar和Scopus等数据库中进行检索，检索期至2023年3月。在删除重复文章并根据资格标准进行筛选后，剩下5篇文章被考虑进行系统回顾和荟萃分析。荟萃分析结果显示，番茄红素组和皮质类固醇组在治疗后减轻疼痛和改善临床症状方面没有明显差异。番茄红素的耐受性良好，没有出现特殊的不良反应。系统综述结果表明，番茄红素对治疗 OLP 有显著效果。这项荟萃分析的结果是有用的，因为番茄红素没有明显的副作用。因此，番茄红素可替代类固醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of HerbMed Pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Journal of Herbmed Pharmacology (J Herbmed Pharmacol) is the intersection between medicinal plants and pharmacology. This international journal publishes manuscripts in the fields of medicinal plants, pharmacology and therapeutic. This journal aims to reach all relevant national and international medical institutions and persons in electronic version free of charge. J Herbmed Pharmacol has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of diseases. A further aim of this journal is to emphasize and strengthen the link between herbalists and pharmacologists. In addition, J Herbmed Pharmacol welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical pharmacology. Contributions in any of these formats are invited for editorial consideration following peer review by at least two experts in the field.