Moringa oleifera and its application in dental conditions: A systematic review and meta-analysis

Q3 Pharmacology, Toxicology and Pharmaceutics

Journal of HerbMed Pharmacology Pub Date : 2023-06-01 DOI:10.34172/jhp.2023.35

Moumita Das, N. Panda, Ruchi Bhuyan, S. Bhuyan

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引用次数: 0

Abstract

Moringa oleifera is a considerable ethnomedical herb with various bioactive compounds. This study aimed to analyze the efficacy of M. oleifera in the prevention and management of various oral conditions. A thorough search was conducted on the Web of Science, Scopus, PubMed, and PubMed Central databases. After screening the data on the basis of inclusion and exclusion criteria, 9 studies were considered for further meta-analysis. The analysis was performed on R programming software (version R-4.0.2) and the results were represented by a forest plot. The estimate obtained via common and random effects model for in vitro studies was statistically insignificant (I2 test P > 0.05) with risk ratios of 8.25 (95% CI: 3.76-18.08) and 7.98 (95% CI: 3.64-17.50) and for in vivo studies were statistically significant (I2 test P )0.05 < with risk ratios of 1.12 (95% CI: 0.90-1.40) and 0.97 (95% CI: 0.71-1.32), indicating the efficacy of M. oleifera in oral diseases on animal and clinical trials, whereas it failed to report the efficacy on in vitro level. Future research has to be done to come up with new and more phytoactive compounds from all parts of the plant with proper extraction procedures. The effectiveness of the compounds has to be validated first on in vitro scale followed by clinical trials so that M. oleifera can be used as therapy in preventing and managing oral ailments.

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辣木及其在牙科疾病中的应用：系统回顾与荟萃分析

油辣木是一种具有多种生物活性化合物的重要民族医药草本植物。本研究旨在分析油麻菜在预防和治疗各种口腔疾病方面的功效。研究人员在 Web of Science、Scopus、PubMed 和 PubMed Central 数据库中进行了全面搜索。根据纳入和排除标准对数据进行筛选后，考虑对 9 项研究进行进一步的荟萃分析。分析使用 R 编程软件（R-4.0.2 版）进行，结果以森林图表示。通过共同效应和随机效应模型获得的体外研究估计值在统计学上不显著（I2 检验 P > 0.05），风险比分别为 8.25（95% CI：3.76-18.08）和 7.98（95% CI：3.64-17.50）；体内研究估计值在统计学上显著（I2 检验 P )0.05 <，风险比分别为 1.12 (95% CI: 0.90-1.40) 和 0.97 (95% CI: 0.71-1.32)。未来的研究必须通过适当的提取程序，从植物的各个部分提取出更多新的植物活性化合物。这些化合物的有效性必须首先在体外进行验证，然后再进行临床试验，这样油橄榄才能被用作预防和治疗口腔疾病的疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of HerbMed Pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Journal of Herbmed Pharmacology (J Herbmed Pharmacol) is the intersection between medicinal plants and pharmacology. This international journal publishes manuscripts in the fields of medicinal plants, pharmacology and therapeutic. This journal aims to reach all relevant national and international medical institutions and persons in electronic version free of charge. J Herbmed Pharmacol has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of diseases. A further aim of this journal is to emphasize and strengthen the link between herbalists and pharmacologists. In addition, J Herbmed Pharmacol welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical pharmacology. Contributions in any of these formats are invited for editorial consideration following peer review by at least two experts in the field.