Optimization of HPMC and Na-CMC as Gelling Agents on Physical Properties and Stability in Sunflower Seed Oil Gel Formulation

Sanubari Indah Putri Rahmani, Abdul Karim Zulkarnain
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Abstract

Abstract: In recent years, skincare with natural ingredients is being developed for it has fewer side effects and is relatively suitable for all skin types. One of the potential ingredients from the natural ingredients is sunflower seed oil, which has proven to have potential as a skin moisturizer and fight acne bacteria. The purpose of this study was to make a gel formulation of sunflower seed oil by optimizing the combination of the gelling agent of HPMC and Na-CMC. The Simplex Lattice Design method was used to optimize the gel base with Design Expert software version 13. There were 8 gel formulas made and evaluated including organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. The independent variables in SLD were the amount of HPMC and Na-CMC, while the responses included pH, viscosity, and spreadability. The optimal formula suggested by SLD is a combination of 1.451% HPMC and 1.549% Na-CMC. The optimal formula has a pH of 6.813 ± 0.041, a viscosity of 194.8 ± 2.94 dPas, an adhesion of 6.29 ± 0.50 seconds, and a spreadability of 21.5 ± 10.05 cm2. The optimum prediction formula from the software has no significant difference from the test results which show that the method can be used to predict the physical properties of sunflower seed oil gel preparations. The results of the physical stability test also stated that its physical properties were stable in terms of pH, viscosity, spreadability, and adhesion.
优化 HPMC 和 Na-CMC 作为胶凝剂对葵花籽油凝胶配方物理性质和稳定性的影响
摘要:近年来,天然成分的护肤品正在被开发出来,因为它的副作用较少,而且相对适合所有皮肤类型。葵花籽油是天然成分中的潜在成分之一,已被证明具有皮肤保湿和抗痤疮细菌的潜力。本研究的目的是通过优化 HPMC 和 Na-CMC 胶凝剂的组合来制作葵花籽油的凝胶配方。使用 Design Expert 13 版软件,采用简单网格设计法对凝胶基质进行了优化。共制作并评估了 8 种凝胶配方,包括感官、均匀性、pH 值、粘度、铺展性和粘附性。SLD 中的自变量是 HPMC 和 Na-CMC 的用量,而响应变量包括 pH 值、粘度和铺展性。SLD 提出的最佳配方是 1.451% 的 HPMC 和 1.549% 的 Na-CMC 的组合。最佳配方的 pH 值为 6.813 ± 0.041,粘度为 194.8 ± 2.94 dPas,粘附性为 6.29 ± 0.50 秒,铺展性为 21.5 ± 10.05 平方厘米。软件得出的最佳预测公式与测试结果无明显差异,这表明该方法可用于预测葵花籽油凝胶制剂的物理性质。物理稳定性测试的结果也表明,葵花籽油凝胶制剂在 pH 值、粘度、涂抹性和粘附性方面的物理性质是稳定的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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