Effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats

Abstract

Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.