Antibacterial Activity of Isolated Compounds from Allophylus spicatus (Poir.) Radlk (Sapindacea)

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2023-07-04 DOI:10.1080/22311866.2023.2262951

E. O. Okpala, P. Onocha, Muhammad Shaiq Ali, O. Odeja, Michael Gabriel Ibok, Godfrey Okechukwu Eneogwe, M. Lateef

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Abstract

Abstract Phytochemical investigation on the roots of Allophylus spicatus (Sapindacea) led to the isolation of four compounds, namely cleomiscosin A (1), cleomiscosin C (2), scopoletin (3) and 3-oxotirucalla-7,24-dien-24-oic acid (4). The structures of the compounds were established by spectroscopic analysis: UV, IR, 1D and 2D NMR, EI-MS and HR-EI-MS and compared with the literature. These compounds are reported for the first time from the plant. The compounds showed potent antibacterial activity, marked inhibition against most of the tested bacterial strains: Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Salmonella typhi (ATCC 25923), Klebsiella pneumonia (ATCC 13883), Streptococcus faecalis (ATCC 29212) and Micrococcus luteus (ATCC 10240), with a zone of inhibition between 0.7±0.35 - 16±0.46 mm as compared with the zone of inhibition of Streptomycin (20±0.34 - 31±0.29 mm), a known antibacterial drug used as the standard. The antibacterial activity of the isolated phytochemicals could be responsible for the plant ethno-medicinal uses. GRAPHICAL ABSTRACT

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从 Allophylus spicatus (Poir.) Radlk (Sapindacea) 分离出的化合物的抗菌活性

摘要通过对刺五加（Allophylus spicatus）（无患子属）根部进行植物化学研究，分离出四种化合物，即 cleomiscosin A (1)、cleomiscosin C (2)、scopoletin (3) 和 3-oxotirucalla-7,24-dien-24-oic acid (4)。这些化合物的结构是通过光谱分析确定的：紫外光谱、红外光谱、1D 和 2D NMR、EI-MS 和 HR-EI-MS，并与文献进行了比较。这些化合物是首次从该植物中发现。这些化合物具有很强的抗菌活性，对大多数受试细菌菌株都有明显的抑制作用：铜绿假单胞菌（ATCC 27853）、大肠埃希菌（ATCC 25922）、伤寒沙门氏菌（ATCC 25923）、肺炎克雷伯菌（ATCC 13883）、粪链球菌（ATCC 29212）和黄体微球菌（ATCC 10240），抑制区在 0.7±0.35 - 16±0.46 mm，而作为标准的已知抗菌药物链霉素的抑菌区为 20±0.34 - 31±0.29 mm。分离出的植物化学物质的抗菌活性可能是该植物具有民族药用价值的原因。图表摘要

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

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0.00%

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