Green synthesis, structural elucidation, antimicrobial, and cytotoxic activities of a Schiff base and its Pd(II) complexes

Analytical Chemistry Letters Pub Date : 2023-07-04 DOI:10.1080/22297928.2023.2256333

Akshita Jain, Sarita Beniwal, Naveen Sharma, N. Fahmi

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Abstract

Abstract This paper includes the synthesis of a Schiff base ligand and its palladium(II) complexes by conventional and green microwave-assisted techniques. They were characterized by conductivity measurements, mass spectrometry, FTIR, electronic spectroscopy, 1H NMR, and X-ray powder diffraction techniques. Based on analytical and spectral data, a square planar geometry was proposed for the metal complexes. The ligand(LH) and its metal complex[Pd(L) ] were screened for antimicrobial activity against pathogenic bacterial(Escherichia coli, Staphylococcus aureus) and fungal(Aspergillus niger, Penicillium chrysogenum) strains. Ciprofloxacin and Ketoconazole were used as standard drugs for antibacterial and antifungal activities respectively. The compounds showed moderate activity. The starting material(PdCl ), ligand(LH), and the metal complex [Pd(L) ] were screened for in vitro cytotoxic activity by MTT assay against cancerous cell lines (HeLa, MCF-7). Cisplatin was used as the standard drug. The metal complex, [Pd(L) ] was also screened for cytotoxic activity against normal cell line(HEK 293) to determine the selectivity index. The values of S.I(3.70-4.58) indicated that the complex [Pd(L) ] was more sensitive towards cancerous cell lines than normal cell line and may be studied further to assess its potential as cytotoxic agent. GRAPHICAL ABSTRACT

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一种希夫碱及其钯（II）配合物的绿色合成、结构解析、抗菌和细胞毒活性

摘要本文采用传统和绿色微波辅助技术合成了一种希夫碱配体及其钯（II）配合物。通过电导率测量、质谱、傅立叶变换红外光谱、电子能谱、1H NMR 和 X 射线粉末衍射技术对它们进行了表征。根据分析和光谱数据，提出了金属配合物的正方形平面几何结构。研究人员筛选了配体（LH）及其金属配合物[Pd(L) ]对致病细菌（大肠杆菌、金黄色葡萄球菌）和真菌（黑曲霉、金青霉）菌株的抗菌活性。环丙沙星和酮康唑分别被用作抗菌和抗真菌活性的标准药物。化合物显示出中等活性。通过 MTT 试验筛选了起始材料（PdCl）、配体（LH）和金属复合物 [Pd(L) ]对癌细胞株（HeLa、MCF-7）的体外细胞毒性活性。顺铂被用作标准药物。为了确定选择性指数，还筛选了金属复合物 [Pd(L) ] 对正常细胞系（HEK 293）的细胞毒活性。S.I 值（3.70-4.58）表明，[Pd(L) ]复合物对癌细胞株比正常细胞株更敏感，可进一步研究以评估其作为细胞毒剂的潜力。图表摘要

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来源期刊

Analytical Chemistry Letters

CiteScore

2.30

自引率

0.00%

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