CISPLATIN AND PROGESTERONE SEPARATE AND JOINT ACTION ON RAT THYMUS NUCLEAR PHOSPHOLIPIDS COMPOSITION AND CONTENT

Agapi G. Hovhannisyan, N. R. Hakobyan, Zh. V. Yavroyan, E. Gevorgyan
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Abstract

The antitumor agent cisplatin and progesterone separate and joint action on content of total phospholipids and their individual fractions in nuclei from rat thymus cells were investigated. When used separately, cisplatin and progesterone exhibit its own distinctive properties. Cisplatin reduces, and progesterone, on the contrary, increases the content of total phospholipids. When used together, the effects of these drugs are summed up. Thus total phospholipid content of rat thymus cell nuclei increases by 17% after the joint injection of cisplatin and progesterone. These changes have different effects on quantities of individual phospholipid fractions. It is assumed that the effects of cisplatin and progesterone, both in their separate and joint action, can be mediated by quantitative changes in internuclear lipids that in turn can regulate the main functions of the cell nuclei.
顺铂和黄体酮对大鼠胸腺核磷脂组成和含量的单独和联合作用
研究了抗肿瘤药物顺铂和黄体酮对大鼠胸腺细胞核中总磷脂及其各个部分含量的单独作用和联合作用。在单独使用时,顺铂和黄体酮表现出各自不同的特性。顺铂会减少总磷脂的含量,而黄体酮则会增加总磷脂的含量。当这些药物同时使用时,它们的作用会相加。因此,在联合注射顺铂和黄体酮后,大鼠胸腺细胞核的总磷脂含量增加了 17%。这些变化对单个磷脂组分的数量有不同的影响。据推测,顺铂和黄体酮的作用,无论是单独作用还是联合作用,都可以通过核内脂质的定量变化来介导,进而调节细胞核的主要功能。
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