Pediatric Acute Megakaryoblast Leukemia & Down Syndrome -An Experience of A Single Institute

Abstract

metaphases achieved and GTG banding was carried out for karyotype analysis. In FISH technique Locus specific Identifier RUNX1T1/RUNX1 probe was used. Trisomy 21 was confirmed in stimulated and unstimulated blood culture and by FISH technique. All patients have better survival with standard induction therapy. The present study highlights the screening of all DS patients and their follow up study to understand the progression to AMKL for tailoring therapy regimen.