Sequence Characterization of Anti Tumorigenic (IL12B) and Pro Tumorigenic (IL17A) Ovine Interleukins for an Immune Approach to Cancer Immunotherapy

Abstract

Cancer is a complex illness characterized by uncontrolled cell growth and the spread of abnormal cells throughout the body. Immunotherapy is one of the cancer treatment modalities gained prominence in recent years. Immunotherapy is a type of bio-therapy that works by retraining the patient's immune system to recognize cancer, boosting selectivity, and decreasing side effects. Immune modulation is a complex process involving several cell types and factors. High-dose of IL-12 provides long-term responses in a subset of patients with metastatic melanoma and renal cell carcinoma. IL-17 has been identified as a frequent cytokine in the tumour microenvironment that can have dual roles in cancer growth and tumour eradication. In present study, ovine Interleukin 12B and 17A genes were amplified, cloned, and in silico analyzed for its potential in cancer treatment.