Serum Pentraxin-3 as a Potential Biomarker for Early Detection of Diabetic Nephropathy in Type 2 Diabetes Mellitus: A Cross-Sectional Study

Academia Open Pub Date : 2023-09-20 DOI:10.21070/acopen.8.2023.7971

Noor Naji Khdher, M. Ahmeid, I. Saadoon, Alaa Abdullah Hassan

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Abstract

This cross-sectional study aimed to assess the utility of serum Pentraxin-3 (PTX-3) as a biomarker for the early identification of diabetic nephropathy (DN) in patients with Type 2 Diabetes Mellitus (T2DM). A total of 90 participants, including 30 with T2DM and nephropathy, 30 with T2DM but without nephropathy, and 30 controls, were enrolled. Serum PTX-3 levels were measured, and correlations with clinical parameters were analyzed. The results revealed a significant elevation in serum PTX-3 levels in DN patients with T2DM. PTX-3 exhibited positive correlations with age, disease duration, blood urea, and serum creatinine, indicating its potential relevance to DN development and renal function. Conversely, non-significant negative correlations were observed with BMI and estimated glomerular filtration rate (eGFR). These findings suggest that serum PTX-3 could serve as a valuable biomarker for the early detection of diabetic nephropathy in Type 2 Diabetes Mellitus, potentially aiding in timely intervention and improved patient care. Highlights : Serum PTX-3 levels significantly elevated in Type 2 Diabetes patients with nephropathy, highlighting its potential as an early diagnostic biomarker. Positive correlations observed between PTX-3, age, disease duration, blood urea, and serum creatinine, suggesting its relevance to DN development and renal function. Serum PTX-3 holds promise for timely identification of diabetic nephropathy, facilitating improved patient care. Keywords : Diabetic Nephropathy, Pentraxin-3, Type 2 Diabetes, Biomarker. Early Detection

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血清五胜肽-3 作为早期检测 2 型糖尿病肾病的潜在生物标记物：一项横断面研究

这项横断面研究旨在评估血清五胜肽-3（PTX-3）作为早期识别 2 型糖尿病（T2DM）患者糖尿病肾病（DN）的生物标志物的效用。研究共招募了 90 名参与者，其中包括 30 名患有 T2DM 和肾病的患者、30 名患有 T2DM 但没有肾病的患者以及 30 名对照组患者。研究人员测量了血清 PTX-3 水平，并分析了其与临床参数的相关性。结果显示，患有 T2DM 的 DN 患者血清 PTX-3 水平明显升高。PTX-3 与年龄、病程、血尿素和血清肌酐呈正相关，表明其与 DN 的发展和肾功能有潜在的相关性。相反，与体重指数（BMI）和估计肾小球滤过率（eGFR）呈非显著负相关。这些研究结果表明，血清 PTX-3 可作为早期检测 2 型糖尿病肾病的重要生物标志物，从而有助于及时干预和改善患者护理。亮点：患有肾病的2型糖尿病患者血清PTX-3水平明显升高，突显了其作为早期诊断生物标志物的潜力。在 PTX-3、年龄、病程、血尿素和血清肌酐之间观察到正相关，表明它与糖尿病肾病的发展和肾功能有关。血清 PTX-3 有助于及时发现糖尿病肾病，改善患者护理。关键词：糖尿病肾病五胜肽-3 2型糖尿病生物标志物早期检测

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Academia Open

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