The Progress of Research in Molecular Structure and Function of Histone Deacetylase 6

Abstract

Histone deacetylases (HDACs) family play an important role in the regulation of cell expression. Histone deacetylase (HDAC) 6 is a special member of the family of histone deacetylases proteins. The specific molecular structure of histone deacetylase 6 determines that HDAC6 can specifically deacetylate non-histone proteins and their substrates, and regulate cell growth, metastasis and apoptosis. However, numerous studies have shown that HDAC6 does have a significant impact on certain diseases, such as cancer, central nervous system diseases, etc. Some studies have even found that HDAC6 may extend life span. This paper mainly talks about the structure and function of HDAC6 from several aspects, including the molecular structure of histone deacetylase 6, the effect of HDAC6 inhibitor, the effect of histone deacetylase 6 on Drosophila longevity and the effect of HDAC6 on nervous diseases. Hoping the introduction of this paper can let people understand HDAC6 so that more researchers can pay attention to HDAC6 and do some studies about it, and then lead to more and better research results.