FLOWABILITY PROPERTIES OF BINARY POWDER MIXTURES CONTAINING DATES POWDER (PHEONIX DACTYLIFERA) MIXED WITH LACTOSE MONOHYDRATE AND MICROCRYSTALLINE CELLULOSE BASED EXCIPIENTS
Fara Wahida Ahmad Hamidi, Mohd Shamsul Anuar, A. S. Baharuddin, M. A. P. Mohammed, Mohd Nazli Naim, S. Mohd Tahir
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Abstract
Powder flow is important in powder processing industries to obtain a quality by design product and efficient manufacturing process. Poor powder flowability can cause problems especially during high speed tableting and capsule filling processes. In this study, dates powder (DP), lactose monohydrate powder, and two types of microcrystalline-based powder excipients evaluated for their flow properties as a binary mixture. Angle of repose (AoR), Hausner ratio (HR) and Carr index (CI) were used to characterize the extent of the powder cohesion. The results show that generally, as particle size increases, values of AoR generally decreases, depicting lower flowability characteristics with decreasing binary mixture particle size. However, HR and CI flowability indicators give contrasting flowability characteristics for the binary mixture containing lactose monohydrate and dates powder.
粉末流动性对于粉末加工行业获得优质设计产品和高效生产工艺非常重要。粉末流动性差会造成问题,尤其是在高速压片和胶囊填充过程中。在这项研究中,对大枣粉(DP)、一水乳糖粉和两种微晶基粉末辅料作为二元混合物的流动性能进行了评估。研究采用了休止角(AoR)、豪斯纳比率(HR)和卡尔指数(CI)来表征粉末的内聚程度。结果表明,一般来说,随着粒度的增大,AoR 值通常会减小,这说明随着二元混合物粒度的减小,流动性也会降低。然而,对于含有一水乳糖和红枣粉的二元混合物,HR 和 CI 流动性指标给出了截然不同的流动性特征。