Evaluation of Paraoxonase 1 Serum Level in Male Androgenetic Alopecia Patients

Abstract

: Background: Hair The medical term for male pattern hair loss is androgenetic alopecia (AGA). Cells in the dermal papilla have been shown to be under oxidative stress in AGA patients. Paraoxonase 1 (PON1) is an important antioxidant that prevents oxidation of low-density lipoprotein (LDL) (LDL). Blood PON1 levels may be influenced by inflammation changes and oxidised LDL concentrations. The goal of this study was to compare the blood PON1 levels of male AGA patients with those of healthy controls. Discussion of Topics and Methods This study used a case-control design, with 60 male patients diagnosed with AGA and 20 age-and sex-matched healthy volunteers serving as cases and controls, respectively. People who went to Benha University Hospitals' Dermatology Outpatient Clinic between April 2020 and December 2021 were considered for inclusion. Serum PON1 and HDL levels were lower in AGA patients than in controls. Reduced levels of PON1 were seen in people with AGA, and oxidative stress was identified to be a possible cause. Androgenetic alopecia; paraoxonase 1 (PON1) in serum; male-pattern baldness.