STUDY OF THE CHEMICAL COMPOSITION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF THE AERIAL PART OF LEONURUS CARDIACA

IF 1.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

FARMACIA Pub Date : 2023-10-26 DOI:10.31925/farmacia.2023.5.21

L. Stepanyan

引用次数: 0

Abstract

The effect of various solvents (hexane, diethyl ether, ethyl acetate, isopropyl alcohol) on extraction of phytocomponents of Leonurus cardiaca leaf was studied a long with the antioxidant and antibacterial activity of the obtained extracts. The chemical composition of the obtained extracts was studied by the chemical and spectrophotometric methods. The results showed the presence of various phytocompounds in the extracts. It was found that the non-polar solvent hexane extracted a large amount of esters compared to all selected solvents. It was also established that the most polar solvent, isopropanol, extracted large amounts of fatty acids. More extractives (8.5% yield) were extracted with isopropanol and this extract contained the highest amounts of phenolic compounds (68.8 mg GAE/g) and flavonoids (22.7 mg RE/g). The analysis of the antioxidant activity showed that the isopropanol extract had the best result. The antibacterial analysis showed that all investigated conditionally pathogenic bacteria ( E. Coli , B. subtilis and Salmonella tуphimurium ) were sensitive to all extracts. Rezumat

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研究蝎尾草气生部分各种提取物的化学成分、抗菌和抗氧化活性

研究了各种溶剂（正己烷、二乙醚、乙酸乙酯、异丙醇）对萃取心叶植物成分的影响，以及所获萃取物的抗氧化和抗菌活性。采用化学和分光光度法研究了所获提取物的化学成分。结果表明，提取物中含有多种植物化合物。结果发现，与所有选定的溶剂相比，非极性溶剂正己烷萃取出了大量的酯。同时还发现，极性最强的溶剂异丙醇萃取了大量脂肪酸。用异丙醇萃取的提取物较多（8.5%），酚类化合物（68.8 毫克 GAE/克）和黄酮类化合物（22.7 毫克 RE/克）的含量最高。抗氧化活性分析表明，异丙醇提取物的抗氧化效果最好。抗菌分析表明，所有调查的条件致病菌（大肠杆菌、枯草杆菌和沙门氏菌）对所有提取物都很敏感。热苏马特

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来源期刊

FARMACIA 医学-药学

CiteScore

2.40

自引率

50.00%

发文量

审稿时长

6-12 weeks

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