THE EFFECT PRODUCED BY IL-2 AND IL-15 ON THE PROLIFERATION OF T CELLS IN VITRO IN PATIENTS DIAGNOSED WITH BREAST CANCER

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.24

S. V. Timofeeva, S.Yu. Filippova, A. Sitkovskaya, I. A. Novikova, O.I. Kit, S.S. Mezentsev, L.N. Vashchenko, E. Kechedzhieva, I. Dashkova, T. V. Ausheva

引用次数: 0

Abstract

Over the past decade, the use of adoptive immunotherapy has emerged as a promising approach to treatment of various malignancies, including breast cancer. Cytokines are involved in the development, differentiation and homeostasis of the T cells. Despite the similarities in signaling pathways, the γc cytokines shape the T cell responses differently: IL-2 plays a major role in the development and maintenance of the regulatory T cells, while IL15 stimulates the proliferation and cytotoxic functions of the CD8+ T cells and NK- cells that leads to an enhanced antitumor response. It is of interest to study the combined effect of these cytokines in an experiment.

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il-2和il-15对乳腺癌患者体外T细胞增殖的影响

在过去十年中，采用免疫疗法已成为治疗包括乳腺癌在内的各种恶性肿瘤的一种前景广阔的方法。细胞因子参与 T 细胞的发育、分化和平衡。尽管信号通路相似，但γc 细胞因子对 T 细胞反应的影响却各不相同：IL-2 在调节性 T 细胞的发育和维持中起主要作用，而 IL15 则刺激 CD8+ T 细胞和 NK- 细胞的增殖和细胞毒性功能，从而增强抗肿瘤反应。我们有兴趣在实验中研究这些细胞因子的综合效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.