SEARCH FOR NEW INHIBITORS OF PROTEIN KINASE SIGNALING PATHWAYS USING MOLECULAR DYNAMICS AND MOLECULAR DOCKING METHODS

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.7

A.A. Glushko, I.P. Kodonidi, E. Frantsiyants, I. Kaplieva, A. S. Chiryapkin, E.V. Sergienko

引用次数: 0

Abstract

The development of new therapeutic strategies for the treatment of various diseases associated with impaired protein kinase activity is one of the most urgent tasks in modern medicine. The search for new protein kinase inhibitors is an effective approach in the struggle against cancer. However, the existing protein kinase inhibitors may have limitations in their effectiveness or may produce undesired side effects. Therefore, the development of new methods for searching for new inhibitors, which should be more effective and safe, is a topical issue. One of the promising areas is the use of molecular modeling to search for new protein kinase inhibitors.

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利用分子动力学和分子对接方法寻找蛋白激酶信号通路的新抑制剂

开发治疗与蛋白激酶活性受损有关的各种疾病的新疗法是现代医学最紧迫的任务之一。寻找新的蛋白激酶抑制剂是抗击癌症的有效方法。然而，现有的蛋白激酶抑制剂可能在有效性方面存在局限性，或者会产生不良副作用。因此，开发更有效、更安全的新方法来寻找新的抑制剂是一个热点问题。利用分子建模寻找新的蛋白激酶抑制剂是其中一个很有前景的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.