Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa

Abstract

Objectives

This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism.

Methods

In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab.

Results

BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab.

Conclusions

Romosozumab is useful for treating osteoporosis in patients with anorexia nervosa.