Twinship and childhood atopic disease: understanding early-life factors among discordant twins

Abstract

Parents often question why one of their children would have asthma while their siblings do not. With twins, this is especially perplexing. The gene-environment interaction hypothesis suggests that early-life environmental exposures interact with genes, leading to asthma and atopic diseases. This study sought to investigate twins for potential early-life risk factors that modify the risk of asthma, allergic rhinitis