Cytokine storm in Chikungunya: Can we call it multisystem inflammatory syndrome associated with Chikungunya?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-01 DOI:10.1016/j.reuma.2023.10.003

Zoilo Morel , Tamara Martínez , Fernando Galeano , Judith Coronel , Lorena Quintero , Rolando Jimenez , Jorge Ayala , Sara Amarilla , Dolores Lovera , Celia Martínez de Cuellar

引用次数: 0

Abstract

Paraguay is currently facing a new outbreak of Chikungunya virus. This report summarizes two severe cases of Chikungunya (CHIKV) infection, confirmed by real-time reverse transcription polymerase chain reaction. We present the cases of patients with acute CHIKV infection and multisystem involvement, with fever, rash, abdominal pain, vomiting, myocarditis, and coronary artery anomalies, very similar to the cases described in MIS-C related to SARS-CoV-2 during the COVID-19 Pandemic. Both patients received IVIG and methylprednisolone, with good clinical response. In this setting of cytokine storm in Chikungunya, can we call it “Multisystem inflammatory syndrome associated with Chikungunya”?.

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基孔肯雅病毒的细胞因子风暴：我们可以将其称为与基孔肯雅病相关的多系统炎症综合征吗？

巴拉圭目前正面临基孔肯雅病毒的新一轮爆发。本报告概述了经实时反转录聚合酶链反应证实的两例基孔肯雅病毒（CHIKV）严重感染病例。我们报告的病例是基孔肯雅病毒急性感染和多系统受累的患者，伴有发热、皮疹、腹痛、呕吐、心肌炎和冠状动脉异常，与 COVID-19 大流行期间与 SARS-CoV-2 相关的 MIS-C 中描述的病例非常相似。两名患者均接受了静脉注射免疫球蛋白和甲基强的松龙治疗，临床反应良好。在基孔肯雅病毒引起细胞因子风暴的情况下，我们是否可以称之为 "与基孔肯雅病毒相关的多系统炎症综合征"？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.