Role of Pharmacokinetics and Pharmacogenetics of Antidepressant-Induced Prolongation of the QT Interval and Torsade de Pointes in Patients with Mental Disorders

Personalized Psychiatry and Neurology Pub Date : 2023-11-15 DOI:10.52667/2712-9179-2023-3-2-72-119

www.JPPN.ru, N. Shnayder, Alla V. Kidyaeva, E. Vaiman, A. Asadullin, Marina M Petrova, D. S. Kaskaeva, Gennady V. Matyushin, Aleksandr A. Evsyukov, Elena V. Galko, N. Garganeeva, Galina A Chumakova, N. Lareva, Nikolai G. Neznanov, Regina F. Nasyrova, В. .. Presynaptic, Monoamine Reuptake, Nonselective Presynaptic Monoamine, Reuptake, Tricyclic Antidepressants

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Abstract

Antidepressants (ADs) include drugs of various pharmacological groups, which are mainly used for the treatment of mental disorders (major depressive disorder, obsessive-compulsive disorder, social phobia, panic disorder, generalized anxiety disorder, post-traumatic stress disorder), chronic pain and addiction diseases. Chronic use of ADs can lead to the development of cardiotoxic adverse drug reactions (ADRs). The most important cardiotoxic AD-induced ADRs are prolongation of the QT interval, ventricular tachycardia of the "pirouette" type (Torsades de Pointes - TdP). This narrative review analyzes and summarizes the results of studies on pharmacokinecis and pharmacogenetics of ADs on QT interval prolongation and updates physicians' knowledge of the risk of developing AD-induced TdP in patients with psychiatric disorders.

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抗抑郁剂诱发精神障碍患者 QT 间期延长和 Torsade de Pointes 的药代动力学和药物遗传学的作用

抗抑郁药（ADs）包括不同药理类别的药物，主要用于治疗精神障碍（重度抑郁症、强迫症、社交恐惧症、恐慌症、广泛性焦虑症、创伤后应激障碍）、慢性疼痛和成瘾性疾病。长期服用抗抑郁药会导致心脏毒性药物不良反应（ADR）的发生。最重要的心脏毒性 AD 引起的不良反应是 QT 间期延长、"回旋 "型室性心动过速（Torsades de Pointes - TdP）。这篇叙述性综述分析并总结了有关抗抑郁药对 QT 间期延长的药代动力学和药物遗传学的研究结果，并更新了医生对精神疾病患者发生抗抑郁药所致 TdP 风险的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Personalized Psychiatry and Neurology

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