Synthesis of Aromatic Macrodiolides and Study of Their Antitumor Activity In Vitro

Abstract

: Based on (5 Z ,9 Z )-tetradeca-5,9-diene-1,14-dioic acid, previously undescribed polyether aromatic macrodiolides were synthesized in good yields (53–67%). The cytotoxicity of the resulting macrocyclic compounds in vitro against tumor Jurkat cells