Search for predictors of psoriatic arthritis in patients with psoriasis

Q4 Medicine

Vestnik dermatologii i venerologii Pub Date : 2023-11-16 DOI:10.25208/vdv14871

O. G. Artamonova, A. Karamova, A. Kubanov, D. A. Verbenko, I. V. Kozlova

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Abstract

Background: Psoriatic arthritis is a chronic inflammatory disease of the joints, spine, and entheses that can occur in patients with psoriasis. The prevalence of psoriatic arthritis is 19.7%. In 70% of cases, psoriasis precedes the development of arthritis. It has been proven that a delay in the diagnosis of psoriatic arthritis even by 6 months is associated with a deterioration in long-term radiological and functional results, leading to disability. The problem of early diagnosis of joint damage can be solved by identifying predictors of the risk of developing psoriatic arthritis in patients with psoriasis. Aims: to determine possible predictors for the development of psoriatic arthritis in patients with psoriasis. Materials and methods: The open, uncontrolled, prospective study enrolled 250 patients. The main group consisted of 190 patients diagnosed with plaque psoriasis. The control group consisted of 60 patients with psoriatic arthritis. In order to identify associations of clinical and genetic (HLA-B27 carriage) parameters with the development of psoriatic arthritis, we compared the frequency of occurrence of these parameters in patients with psoriatic arthritis and without. Results: Among 190 patients with plaque psoriasis 128 (67.4%) men, 62 (32.6%) women, aged 18 to 84 years (40.3015.56), the average duration of psoriasis was 10.0911, 08 (0-57 years). Among 60 patients with psoriatic arthritis 39 (65%) men, 21 (35%) women aged 18 to 86 years (44.4314.15), the average duration of psoriasis was 20.4713.22 (2-57 years), the average duration of psoriatic arthritis was 7.979.95 (047 years). Сlinical predictors for the development of psoriatic arthritis in patients with psoriasis: nail psoriasis (OR=2.244 [95% CI: 1.245 - 4.045]), severe psoriasis (PASI20) (OR=2.148 [95% CI: 1.161 - 3.975), arterial hypertension (OR = 1.982 [95% CI: 1.031 - 3.812]), duration of psoriasis over 25 years (OR = 3.365 [95% CI: 1.676 - 6.756), р0,05 Conclusions: The joint consideration of informative predictors will allow us to develop an original multi-parameter mathematical model for calculating the risk of developing psoriatic arthritis in patients with psoriasis.

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寻找银屑病患者银屑病关节炎的预测因素

背景：银屑病关节炎是银屑病患者关节、脊柱和粘膜的一种慢性炎症性疾病。银屑病关节炎的发病率为 19.7%。在 70% 的病例中，银屑病先于关节炎发生。事实证明，银屑病关节炎的诊断即使延迟 6 个月，也会导致长期放射学和功能结果的恶化，从而导致残疾。通过确定银屑病患者患银屑病关节炎风险的预测因素，可以解决早期诊断关节损伤的问题。目的：确定银屑病患者发生银屑病关节炎的可能预测因素。材料与方法：这项开放、非对照、前瞻性研究共招募了 250 名患者。主研究组由 190 名确诊为斑块状银屑病的患者组成。对照组由 60 名银屑病关节炎患者组成。为了确定临床和遗传（HLA-B27携带）参数与银屑病关节炎发病的关系，我们比较了银屑病关节炎患者和非银屑病关节炎患者出现这些参数的频率。结果发现在 190 名斑块状银屑病患者中，男性 128 人（67.4%），女性 62 人（32.6%），年龄在 18 至 84 岁（40.3015.56）之间，银屑病的平均病程为 10.0911.08（0-57 年）。在 60 名银屑病关节炎患者中，男性 39 人（65%），女性 21 人（35%），年龄在 18-86 岁之间（44.4314.15），银屑病的平均病程为 20.4713.22（2-57 年），银屑病关节炎的平均病程为 7.979.95（047 年）。银屑病患者发生银屑病关节炎的临床预测因素：指甲银屑病（OR=2.244 [95% CI：1.245 - 4.045]）、重度银屑病（PASI20）（OR=2.148 [95% CI: 1.161 - 3.975]）、动脉高血压（OR=1.982 [95% CI: 1.031 - 3.812]）、银屑病病程超过 25 年（OR=3.365 [95% CI: 1.676 - 6.756]），р0.05 结论：综合考虑各种信息性预测因素，我们可以建立一个独创的多参数数学模型，用于计算银屑病患者罹患银屑病关节炎的风险。

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