Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.)

Q3 Chemistry

Molekul Pub Date : 2023-11-20 DOI:10.20884/1.jm.2023.18.3.6872

Undri Rastuti, S. Widyaningsih, M. Chasani, Ranti Kamila Habibie, Vani Fitria Rosita Elly, Sity Khalidah Zia

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Abstract

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan

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肉豆蔻叶精油纳米乳液（Myristica fragrans Houtt.）

肉豆蔻叶精油（Myristica Fragrans Houtt.）是具有抗氧化活性和防晒潜力的天然成分之一。这项研究旨在配制肉豆蔻叶精油纳米乳液，分析其特性并确定其作为防晒剂的功效。研究人员使用两种不同的表面活性剂配制了 1、3 和 5 毫升油含量的肉豆蔻叶精油纳米乳液。表征包括感官、pH 值、粘度、%T、纳米乳液类型、液滴大小、热力学和离心稳定性测试。使用紫外可见分光光度计在 290-400 纳米波长范围内进行评估，以乙醇作为空白和非纳米乳液作为对比。结果表明，肉豆蔻叶精油纳米乳液外观清晰稳定，对皮肤安全，粘度值小于 200 mPas，%T 值接近 100%，纳米乳液类型为 O/W，粒径小于 200 nm。评价结果表明，肉豆蔻叶油纳米乳液的防晒活性高于非纳米乳液。防晒活性最高的是配方 A 纳米乳液，其含油量为 5 mL，SPF 值为 1.475；%Te 值为 50.571%；%Tp 值为 77.218%。配方 A 的纳米乳液的防晒活性被归类为普通晒黑剂。

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