A Comprehensive Review of the Pharmacological Effects of Genus Ferula on Central Nervous System Disorders

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2023-11-21 DOI:10.2174/0118715249256485231031043722

S. Bagheri, M. esmailidehaj

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引用次数: 0

Abstract

Background: Plants of the genus Ferula have long been used to treat neurological diseases such as Alzheimer's disease (AD), pain, depression, and seizures. The main compounds include coumarins, monoterpenes, sulfide compounds, and polyphenol compounds, which can improve the functioning of the nervous system. Objective: This article has been compiled with the aim of collecting evidence and articles related to the Ferula effects on central nervous system disease. Methods: This review article was prepared by searching the terms Ferula and analgesic, anticonvulsant, antidepressant, anti-multiple sclerosis, anti-dementia, and neuroprotective effects.The relevant information was collected through searching electronic databases such as ISI Web of Knowledge, PubMed, and Google Scholar. Results: Genus Ferula has a protective effect on nerve cells by reducing cytokines such as IL-6, IL1b, and TNF-α. Therefore, the effects of Ferula plants and their effective ingredients can be used to prevent or improve diseases that destroy the nervous system. The members of this genus play a role in strengthening and improving the antioxidant system, reducing the level of oxidative stress, and inhibiting or reducing inflammatory factors in the nervous system. Conclusion: Although the effects of several species of Ferula on the nervous system have been investigated, most studies have not clearly identified the molecular mechanisms as well as the specific functional regions of the brain. The present study was compiled in order to investigate different aspects of the effects of Ferula plants on the central nervous system.

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阿魏属植物对中枢神经系统疾病的药理作用综述

背景：阿魏属植物长期以来一直被用于治疗阿尔茨海默病（AD）、疼痛、抑郁症和癫痫发作等神经系统疾病。其主要化合物包括香豆素、单萜烯、硫化物和多酚化合物，可改善神经系统的功能。研究目的本文旨在收集有关阿魏对中枢神经系统疾病影响的证据和文章。方法：通过检索 ISI Web of Knowledge、PubMed 和 Google Scholar 等电子数据库，收集相关信息。研究结果阿魏属植物通过减少 IL-6、IL1b 和 TNF-α 等细胞因子对神经细胞有保护作用。因此，阿魏属植物及其有效成分可用于预防或改善破坏神经系统的疾病。阿魏属植物在加强和改善抗氧化系统、降低氧化应激水平、抑制或减少神经系统炎症因子方面发挥着作用。结论：虽然已经研究了几种阿魏对神经系统的影响，但大多数研究还没有明确确定其分子机制以及大脑的特定功能区域。本研究旨在调查阿魏植物对中枢神经系统不同方面的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.

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