Progress in the Design of Molecular Targeted Drugs for Gastric Cancer

Abstract

Gastric cancer is one of the most common cancers in China, and its pathogenesis is related to many molecular signaling pathways and related factors. The more critical molecular pathways include MET pathway, PI3K / AKT pathway, and MAPK pathway. In addition, the EGFR family and factors related to tumor angiogenesis are also important factors, which are closely related to tumor cell proliferation, apoptosis, and metastasis. The results of the study will provide new ideas and methods for the treatment of gastric cancer and lay the groundwork for the development of new gastric cancer drugs. On this basis, a variety of molecular targeted drugs have entered the clinical trial stage, among which, trastuzumab and apatinib have shown good efficacy. This paper summarizes the molecular pathogenesis of gastric cancer, and summarizes the mechanism of action, combination chemotherapy and research progress of trastuzumab and apatinib, so as to provide reference for future research on targeted therapy for gastric cancer.