The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical Cancer

Q3 Medicine

Current Signal Transduction Therapy Pub Date : 2023-11-24 DOI:10.2174/0115743624273536231105142321

Sajad Najafi, Farhoodeh Ghaedrahmati, Mahrokh Abouali Gale Dari, Maryam Farzaneh, R. Mohammad Jafari

引用次数: 0

Abstract

Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs (circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells, making them a promising biomarker for diagnosis and treatment. This review provides an overview of the functional roles of circRNAs in the context of cervical cancer.

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宫颈癌中作为 miRNA 海绵的环状 RNA 的调控作用

宫颈癌是第四大最常诊断出的癌症，也是导致女性癌症相关死亡的第四大原因。宫颈癌是一种受各种遗传、表观遗传和环境因素影响的复杂疾病。虽然有放疗、化疗和激素治疗等治疗方法，但由于远处转移和淋巴转移率高，预后仍然很差。最近的研究揭示了非编码 RNA（ncRNA）在宫颈癌发展中的作用，其中环状 RNA（circRNA）成为细胞过程的潜在重要调控因子。通过靶向 miRNAs/mRNAs，circRNAs 可影响宫颈癌细胞的生长和侵袭，使其成为诊断和治疗的一种有前景的生物标记物。本综述概述了 circRNA 在宫颈癌中的功能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Signal Transduction Therapy 医学-药学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders. The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases. Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.