S. Aneja, Arun Mittal, Neerupma Dhiman, Gaurav Agarwal
{"title":"A Review on Phytoconstituents for the Treatment of Psoriasis","authors":"S. Aneja, Arun Mittal, Neerupma Dhiman, Gaurav Agarwal","doi":"10.5530/phrev.2023.17.8","DOIUrl":null,"url":null,"abstract":"Psoriasis once thought to be largely an epidermal keratinocyte problem, it is now understood that it is a disorder due to immune-mediation. Skin hyperplasia of vascular hyperplasia, epidermal keratinocytes, and permeation of neutrophils, leucocytes, and extra types of T lymphocytes in affected skin. The pathophysiology of the illness is intricate and includes both genetic and cellular elements. As a result, there are many different therapeutic approaches that work on various targets, ranging from symptomatic treatment to immune system modulation. Drugs are known to cause the condition but the precise cause of it is uncertain. Environmental factors like smoking, infections and seasonal changes are also responsible. Natural alternatives are being sought after due to the harmful impact on life quality and dangerous adverse effects of conventional treatment. There are a variety of plants that have been utilized in conventional psoriasis treatment methods that could serve as safer substitutes. The emphasis of the current review article is on pharmacological studies of anti-psoriatic plant, plant extracts, and formulation. The review has also taken into account several chemical elements extracted from plants that are accountable for antipsoriatic activity and their mechanisms of action. This review is necessary to choose these plants for more research in order to identify the chemical components that fight psoriasis and determine how they work.","PeriodicalId":74432,"journal":{"name":"Pharmacognosy reviews","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacognosy reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/phrev.2023.17.8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Psoriasis once thought to be largely an epidermal keratinocyte problem, it is now understood that it is a disorder due to immune-mediation. Skin hyperplasia of vascular hyperplasia, epidermal keratinocytes, and permeation of neutrophils, leucocytes, and extra types of T lymphocytes in affected skin. The pathophysiology of the illness is intricate and includes both genetic and cellular elements. As a result, there are many different therapeutic approaches that work on various targets, ranging from symptomatic treatment to immune system modulation. Drugs are known to cause the condition but the precise cause of it is uncertain. Environmental factors like smoking, infections and seasonal changes are also responsible. Natural alternatives are being sought after due to the harmful impact on life quality and dangerous adverse effects of conventional treatment. There are a variety of plants that have been utilized in conventional psoriasis treatment methods that could serve as safer substitutes. The emphasis of the current review article is on pharmacological studies of anti-psoriatic plant, plant extracts, and formulation. The review has also taken into account several chemical elements extracted from plants that are accountable for antipsoriatic activity and their mechanisms of action. This review is necessary to choose these plants for more research in order to identify the chemical components that fight psoriasis and determine how they work.
牛皮癣曾被认为主要是表皮角质细胞的问题,但现在人们已经认识到,它是一种由免疫介导引起的疾病。患处皮肤血管增生,表皮角质细胞增生,中性粒细胞、白细胞和额外类型的 T 淋巴细胞渗透。该病的病理生理学错综复杂,既包括遗传因素,也包括细胞因素。因此,有许多针对不同靶点的治疗方法,从对症治疗到免疫系统调节,不一而足。已知药物可导致该病,但确切病因尚不确定。吸烟、感染和季节变化等环境因素也是原因之一。由于传统治疗对生活质量的有害影响和危险的不良反应,人们开始寻求天然的替代疗法。在传统的银屑病治疗方法中,有多种植物可以作为更安全的替代品。本综述文章的重点是抗银屑病植物、植物提取物和制剂的药理学研究。综述还考虑了从植物中提取的几种具有抗银屑病活性的化学元素及其作用机制。有必要通过这篇综述选择这些植物进行更多研究,以确定抗牛皮癣的化学成分,并确定它们的作用机制。