Deadly nuts – detection of 3-nitropropionic acid in coconuts

IF 1.7 4区医学 Q3 FOOD SCIENCE & TECHNOLOGY

World Mycotoxin Journal Pub Date : 2023-11-30 DOI:10.1163/18750796-20232879

K. Ringsborg Westphal, N. Vittrup Andersen, B. Uttrup Dideriksen, A. Filtenborg Gunggaard, M.A. Duus, T.E. Sondergaard

引用次数: 0

Abstract

The secondary metabolite 3-nitropropionic acid (3-NPA) is produced by certain fungi. The metabolite is a potent toxin which inhibits the citric acid cycle. A medical case from 2021 described a 69-year-old Danish man who ingested 3-nitropropionic acid contaminated coconut water. The man died 26 hours after ingestion. Subsequent analysis identified Apiospora saccharicola as the fungi responsible for synthesising 3-NPA in the coconut. The metabolic pathway for 3-NPA is unknown but is thought to be activated by adverse growth conditions. This study aimed to confirm that Apiospora can produce 3-NPA within coconuts and develop a quick and easy method for detection of 3-NPA in coconut water using 1H NMR. This method can possibly aid in detection of 3-NPA in contaminated groceries, such as coconut water.

查看原文本刊更多论文

致命的坚果 - 检测椰子中的 3-硝基丙酸

某些真菌会产生次级代谢产物 3-硝基丙酸（3-NPA）。这种代谢物是一种强效毒素，会抑制柠檬酸循环。2021 年的一个医疗案例描述了一名 69 岁的丹麦男子摄入了受 3-硝基丙酸污染的椰子汁。该男子在摄入 26 小时后死亡。随后的分析发现，椰子中的 Apiospora saccharicola 是合成 3-NPA 的真菌。3-NPA 的代谢途径尚不清楚，但据认为会在不利的生长条件下被激活。本研究旨在证实 Apiospora 能在椰子中产生 3-NPA，并开发出一种快速简便的方法，利用 1H NMR 检测椰子水中的 3-NPA。这种方法可能有助于检测受污染食品（如椰子汁）中的 3-NPA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

World Mycotoxin Journal MYCOLOGY-

CiteScore

4.60

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''World Mycotoxin Journal'' is a peer-reviewed scientific journal with only one specific area of focus: the promotion of the science of mycotoxins. The journal contains original research papers and critical reviews in all areas dealing with mycotoxins, together with opinions, a calendar of forthcoming mycotoxin-related events and book reviews. The journal takes a multidisciplinary approach, and it focuses on a broad spectrum of issues, including toxicology, risk assessment, worldwide occurrence, modelling and prediction of toxin formation, genomics, molecular biology for control of mycotoxigenic fungi, pre-and post-harvest prevention and control, sampling, analytical methodology and quality assurance, food technology, economics and regulatory issues. ''World Mycotoxin Journal'' is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as of policy makers and regulators.