The effect of combining humic and fulvic acids poultice on wound healing in male rats

Q3 Medicine

Journal of Cutaneous and Aesthetic Surgery Pub Date : 2023-11-30 DOI:10.4103/jcas.jcas_92_23

N. Gheibi, Fatemeh Samiee-Rad, M. Sofiabadi, Ebrahim Mosayebi, Zahra Shalbaf

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引用次数: 0

Abstract

Finding new compounds to accelerate wound healing is critical today. Humic substances or fulvic acid each have anti-inflammatory properties. The purpose of this study is to determine the effects of poultice 0.5% containing humic and fulvic acids on wound healing in male rats. An animal model was arranged by making a full-thickness skin wound was created in each rat. Animals were randomly divided into control, sham, and treatment groups. To investigate the effect of humic and fulvic acids combining poultice, the wound area and histological analyses of the number of inflammatory cells, fibroblasts, and angiogenesis were evaluated for 21 days. The animals in the treated group showed higher wound healing percentage, angiogenesis, and fibroblast distribution compared with the control (P < 0.001). Moreover, the topical administration of humic and fulvic acids 0.5% poultice decreased the mean number of inflammatory cells significantly than the other groups (P < 0.001). The topical administration of a poultice containing humic and fulvic acid accelerated wound healing by increasing angiogenesis and fibroblast and reducing inflammatory cell distribution in a rat model.

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腐植酸和富勒酸混合膏药对雄性大鼠伤口愈合的影响

如今，寻找加速伤口愈合的新化合物至关重要。腐殖质或富勒酸都具有抗炎特性。本研究旨在确定含腐植酸和富勒酸的 0.5% 膏药对雄性大鼠伤口愈合的影响。研究安排了一个动物模型，为每只大鼠制作了一个全厚皮肤伤口。动物被随机分为对照组、假治疗组和治疗组。为了研究腐植酸和富勒酸复合膏药的效果，对伤口面积和炎症细胞、成纤维细胞数量及血管生成的组织学分析进行了为期 21 天的评估。与对照组相比，治疗组动物的伤口愈合率、血管生成和成纤维细胞分布均高于对照组（P < 0.001）。此外，腐植酸和富勒酸 0.5%膏药外敷组比其他组明显减少了炎症细胞的平均数量（P < 0.001）。在大鼠模型中，通过增加血管生成和成纤维细胞以及减少炎症细胞分布，局部使用含腐植酸和富勒酸的膏药可加速伤口愈合。

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来源期刊

Journal of Cutaneous and Aesthetic Surgery Medicine-Surgery

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

29 weeks

期刊介绍： The journal will cover aspects of Dermatosurgery and Aesthetic surgery, including cutaneous surgical procedures, lasers, light based treatments and aesthetic treatments. Authors of articles addressing topics such as skin tumours, pigmentary disorders, histopathology, diagnostic techniques, drugs, applications of cosmeceuticals surgical aspects, including pre and post procedural care are highly encouraged to submit with us. The journal also publishes articles on topics in allied specialities suh as plastic surgery, maxillofacial surgery vascular surgery, oculoplastic surgery etc. that are relevant to Dermatosurgery. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed Original Research Articles, Systematic reviews, Narrative Reviews, Case reports, Innovations and Debates. Letters to the editor, practice points, pearls in cutaneous and aesthetic surgery, quiz page, images, novel techniques, newer uses of instruments and video presentations and ethical aspects of cutaneous and aesthetic surgery are also invited.