Efficacy of Nilavembu Kudineer for Dengue Fever Management – An Overview of Clinical and Preclinical Evidences

Abstract

Abstract BACKGROUND AND AIM Dengue viral disease (DVD) is a tropical arboviral disease that is caused by dengue virus (DENV), which is transmitted mainly by the bite of female Aedes aegypti mosquitoes. No specific antiviral drug is approved yet to manage the patients with DENV infection, who are managed using symptomatic therapy and supportive care. AIM As a consequence, we intend to review the potential of Nilavembu kudineer in the management of DENV infection. MATERIALS AND METHODS To find articles pertinent to the clinical, in vitro, and in silico studies evaluating the effectiveness of Nilavembu Kudineer in the management of DENV infection, the literature was searched in databases such as Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, Embase, Directory of open access journals, and reference lists. RESULTS Nilavembu Kudineer may be able to alleviate signs and symptoms experienced by patients with DENV infection, according to few clinical, in vitro, and in silico studies. CONCLUSION The effectiveness of Nilavembu Kudineer in patients with DENV infection would further be demonstrated by additional randomized controlled clinical trials.