Idealization in pharmacology and pharmacy: Symbol of the chemical formula of a one molecule of a substance and real pharmaceutical product

Alexander L. Urakov, P. Shabanov
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Abstract

The fundamentally different essence of two levels of information used in modern pharmacy, pharmacology and medicine for operations related to theoretical reasoning about medicines and the actual practice of their use in the treatment of specific patients is reported. In particular, the essence of theoretical information about medicines and norms of their use in accordance with the standards of medical care is analyzed. It is shown that the information about medicines and standards of medical care, dominating nowadays in textbooks, reference books, encyclopedias, scientific articles and normative and technical documents, is built on the idealized essence of chemically pure substances and idealized essence of their interaction with an idealized virtual patient. In this regard, in the fields of pharmacy, pharmacology, and chemistry, physics, and materials science, researchers to date have traditionally represented chemical elements (and drugs) by certain chemical formulas, names, and symbols for their molecules. Moreover, in pharmacy and pharmacology, the structural formula of one molecule of only one chemical substance belonging to the group of so-called main active substances most often plays this role. As a rule, this chemical symbol of its molecule is identified with the real substance itself. It is assumed that the substance in question is of ideal high quality, it is completely free of any impurities, it is not combined with other substances and does not represent a certain pharmaceutical product (it is not a tablet, not a solution, not an ointment, not an aerosol, etc.), and is not manufactured by a certain pharmaceutical company according to a certain recipe. At the same time, modern pharmaceutical products are not separate molecules, not pure chemical reagents, but all sorts of mixtures of different substances of different quality in different ratios. At the same time, each pharmaceutical product of each manufacturing plant and each series number has only inherent and unique mechanical, physical, chemical, physico-chemical properties and quality indicators. Therefore, the idealized essence of drugs is far from the essence of real pharmaceutical products. The chemical name and chemical formula are just a symbol of one molecule of a chemical element, reflecting its idealized chemical essence, but not the essence of a real "tablet", "ampoule" and/or "tube" with it. In turn, the virtual patient of average gender, average age, average health status, with a body weight of about 70 kg implied by the standards of medical care is just an idealized object of interaction with an idealized "medicine". In this regard, the study of the relationship between the idealized and real essence of drugs and patients is a crucial part of the problem of the relationship between theory and reality in pharmacy, pharmacology and in medicine.
药理学和药剂学中的理想化:一分子物质的化学式符号与实际药品的化学式符号
本报告介绍了现代药剂学、药理学和医学中使用的两级信息的本质区别,这两级信息分别用于有关药物的理论推理和在治疗特定病人时使用药物的实际操作。其中特别分析了关于药物的理论信息和根据医疗标准使用药物的规范的本质。结果表明,目前在教科书、参考书、百科全书、科学文章和规范性技术文件中占主导地位的有关药物和医疗标准的信息,是建立在纯化学物质的理想化本质及其与理想化虚拟病人相互作用的理想化本质之上的。在这方面,迄今为止,在药剂学、药理学以及化学、物理学和材料科学领域,研究人员传统上都是用一定的化学式、名称和分子符号来表示化学元素(和药物)。此外,在药剂学和药理学中,属于所谓主要活性物质组的一种化学物质的一个分子的结构式最常起这种作用。通常,这种分子的化学符号与实际物质本身是一致的。假定有关物质具有理想的高质量,完全不含任何杂质,没有与其他物质结合,不代表某种药 品(不是片剂、溶液、软膏、气雾剂等),也不是由某个制药公司按照某种配方生产的。同时,现代药品不是独立的分子,不是纯化学试剂,而是由不同质量的物质按不同比例混合而成的各种混合物。同时,每个生产厂、每个系列号的每种药品都只有固有的、独特的机械、物理、化学、理化性质和质量指标。因此,理想化的药品本质与真实的药品本质相去甚远。化学名和化学式只是一种化学元素一个分子的符号,反映的是其理想化的化学本质,而不是真正的 "片剂"、"安瓿 "和/或 "管剂 "的本质。反过来,按照医疗标准,一般性别、一般年龄、一般健康状况、体重约 70 公斤的虚拟病人也只是与理想化的 "药物 "相互作用的理想化对象。因此,研究药物和病人的理想化本质与现实本质之间的关系,是药学、药理学和医学中 理论与现实关系问题的重要组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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