Psychotherapy, pharmacotherapy, and their combination in the treatment of major depressive disorder: How well are we making use of available therapies?

Q4 Pharmacology, Toxicology and Pharmaceutics
Ingrid Nădășan, G. Hancu
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Abstract

Abstract Major depressive disorder stands as a profound challenge in the realm of psychiatric illnesses disrupting the well-being and daily existence of affected individuals. This heterogeneous condition continues to baffle researchers due to the elusive nature of its full neurological mechanisms. This review delves into the complex landscape of major depressive disorder, exploring the diverse therapeutic avenues available, from the nuanced realms of psychotherapy to the pharmacological and non-pharmacological approaches that have been the focus of extensive research. In the relentless pursuit of relief for those afflicted, substantial efforts and resources are tirelessly channeled into the exploration of novel antidepressants and the refinement of existing therapeutic protocols. This review juxtaposes the efficiencies of existing treatments, unraveling their comparative effectiveness, and shedding light on their respective strengths and limitations. Even so, the question remains, how well are we managing the treatment of major depressive disorder, and which is the best option not only to treat this condition but also to reach full remission. Consequently, we have compiled findings on treatment selections and how efficient they are in relation to each other. The more we understand how to treat depression effectively the more we can improve the quality of life of individuals affected by this disorder. By comprehensively evaluating the diverse modalities, this review aims to guide clinicians and researchers toward evidence-based decisions, facilitating the formulation of individualized and targeted treatment protocols.
治疗重度抑郁障碍的心理疗法、药物疗法及其组合:我们对现有疗法的利用率如何?
摘要 重度抑郁障碍是精神疾病领域的一大难题,它扰乱了患者的身心健康和日常生活。由于重度抑郁障碍的全部神经机制难以捉摸,研究人员一直对这种异质性疾病感到困惑。这篇综述深入探讨了重度抑郁障碍的复杂情况,探索了从心理治疗的细微领域到药物和非药物方法等多种治疗途径,这些都是广泛研究的重点。为了不懈地为患者寻求解脱,大量的精力和资源被孜孜不倦地投入到新型抗抑郁药物的探索和现有治疗方案的改进中。本综述将现有治疗方法的效率并列起来,揭示它们的比较有效性,并阐明它们各自的优势和局限性。即便如此,问题依然存在:我们对重度抑郁障碍的治疗管理得如何,哪种方法不仅是治疗这种疾病的最佳选择,也是达到完全缓解的最佳选择。因此,我们汇编了有关治疗方法选择的研究结果,以及这些治疗方法之间的效率关系。我们对如何有效治疗抑郁症了解得越多,就越能提高抑郁症患者的生活质量。通过全面评估各种治疗方法,本综述旨在指导临床医生和研究人员做出以证据为基础的决定,从而促进制定个性化和有针对性的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
24 weeks
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